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Table 3 Subanalysis in IDC cases: immunohistochemical variables

From: Hsp90 in the continuum of breast ductal carcinogenesis: Evaluation in precursors, preinvasive and ductal carcinoma lesions

Univariable analysis

Variables

N (%)

Hsp90 Allred score

p

Triple-negative status§

  

0.0004 MWW

Triple-negative

9 (17.7%)

6.44 ± 1.01

 

Non-triple-negative

42 (82.3%)

7.52 ± 0.55

 

ER Allred score

  

0.004 S

< median

23 (45.1%)

7.04 ± 0.93

 

≥median

28 (54.9%)

7.57 ± 0.50

 

PR Allred score

  

0.020 S

< median

21 (41.2%)

6.95 ± 0.86

 

≥median

30 (58.8%)

7.60 ± 0.56

 

c-erbB-2 status

  

0.011 MWW

Negative

29 (56.9%)

7.10 ± 0.86

 

Positive

22 (43.1%)

7.64 ± 0.49

 

Multivariable analysis

Variables

Category or increment

OR (95% CI)

p

ER Allred score

1 point increase

1.29 (0.99-1.66)

0.055

PR Allred score

1 point increase

1.18 (0.92-1.51)

0.195

c-erbB-2 status

Positive vs. negative

1.85 (1.14-3.02)

0.013

  1. MWWp-value derived from Mann-Whitney-Wilcoxon test for independent samples; Sp-value derived from Spearman's rank correlation coefficient; § not included in the multivariable analysis, as it integrates all three components (ER, PR, c-erbB-2); ER Allred score, PR Allred score have been treated as continuous variables and thus the subcategories serve purely descriptive purposes practical interpretation: increase in Allred score by one unit predicts OR = 1.29.