Skip to main content

Table 1 Colony growth of leukemia cells and normal bone marrow in response to treatment with organosulfur compounds

From: Characterization of the apoptotic response of human leukemia cells to organosulfur compounds

Group Compound Name Structure Dose (μM) Selectivity
     AML NBM
I F2 CH3SO2CH2CH2SSCH2CH2SO2CH3 ND   
  F3 CH3SO2CH2CH2SSPh ND   
  H1 CH3OC(O)CH2CH2SSCH3 ND   
II F CH3SO2CH2CH2SSCH3 100 ++ +
  F1 CH3SO2CH2CH2SSCH2CO2CH3 100 +++ +
  H CH 3 OC(O)CH 2 SSCH 3 175 ++ -
  H2 CH3OC(O)CH2SSCH2CH2CH3 50 ++ +
  H5 CH 3 OC(O)CH 2 SS(CH 2 ) 6 CH 3 200 +++ -
  H6 CH3(CH2)5OC(O)CH2SSCH2CH2CH3 50 + +
  K CH3SO2CH2SSCH2CH2CH2CH2CH3 50 +++ ++
  L CH 3 SO 2 SPh 50 ++ -
  N CH 3 SCH 2 SSCH 3 100 ++ -
  N2 CH3SCH2SSCH2CH2CH2SO2CH3 50 ++ +
  O CH 3 OC(O)CH 2 SSCH 2 C(O)OCH 3 100 ++ -
  P PhC(O)CH 2 SSCH 3 100 ++ -
  Q PhSSCH2OC(O)CH2CH3 50 ++ ++
III F4 CH3SO2CH2CH2SS(C6H4)OCH3 20 ++ +
  F5 CH3SO2CH2CH2SS(C6H4)NO2 20 +++ +++
  F6 CH3(C6H4)SO2CH2CH2SSCH3 40 +++ +++
  F7 CH3(C6H4)SO2CH2CH2SSPh 30 ++ +
  F8 CH3(C6H4)SO2CH2CH2SSCH2CH2SO2(C6H4)CH3 20 +++ ++
  H3 CH3OC(O)CH2SS(C6H4)OCH3 ND   
  H4 CH3OC(O)CH2SSPh 25 + -
  H7 CH3(CH2)5OC(O)CH2S SPh 25 + -
  H8 CH3OC(O)CH2SS(C6H4)NO2 ND   
  M O2N(C6H4)SSCH3 50 +++ +++
  N1 CH3SCH2SSCH2SCH2SO2CH3 50 +++ +++
  1. Results of compounds assayed for specificity and sensitivity to leukemic cell lines and normal bone marrow using colony growth assay. The colony growth assay results for compounds K, L, M, N, O, P and Q were repeated a minimum of three independent times with consistent results. Colony growth assay results for the remaining compounds were repeated twice. Data is summarized as the fraction of colonies formed compared to solvent controls, and indicated as >0.75 (-, no effect), 0.75 (+), 0.50 (++), and >0.25 (+++). Compounds with tumor-specific activity are shaded. Abbreviations: AML, Acute Myelogenous Leukemia; NBM, normal bone marrow; ND, not determined