Figure 3

Box-Plot analysis of EpEx expression in thyroid cancers. Box plots showing distribution of total immunostaining scores determined by immunohistochemistry in paraffin-embedded sections of normal thyroid tissues and different types of thyroid cancers. The vertical axis gives the total immunostaining score, obtained as described in the Methods section. Upper panel depicts the membranous EpEx localization in normal tissues and PTC, no detectable expression in ATC and varying reduced expressions in Insular, FTC and SCC (with a median score of 3, bold horizontal line). The lower panel depicts cytoplasmic EpEx localization in normal tissues, PTC, PDPTC, PDFTC, insular and FTC, no detectable expression in ATC and varying reduced expression in SCC. No detectable nuclear EpEx staining was observed in normal tissues, or in any of the subtypes of TC, hence this box plot was not included in the figure.