Figure 2

Differential immunohistochemical expression of EpEx, Ep-ICD and β-catenin proteins in different regions of an ATC tumor with varying degrees of aggressive tumor pathology. No membranous EpEx staining was observed in the ATC tissue section (IA), faint membranous EpEx staining in tissue section showing squamous cell carcinoma (IB), membranous EpEx staining in both poorly differentiated TC section and the adjacent normal thyroid tissue section (IC, ID). Nuclear and cytoplasmic Ep-ICD staining in undifferentiated and poorly differentiated TC tissue sections (IIA-IIC), membranous and cytoplasmic staining in the adjacent thyroid normal tissue (IID). Nuclear and cytoplasmic β catenin staining in ATC section (IIIA), membranous β catenin staining in different regions of this tumor with varying degrees of aggressive tumor pathology (IIIB-IIID). A-D, original magnification × 10.