Figure 6

Reduced expression of transcripts coding MMP-2, MMP-9 and TNF-α in melanoma tumors recovered from HB-19 treated RET mice. The expression of transcripts coding MMP-2, MMP-9, VEGF-A, TNF-α, STAT-1, MIA and GAPDH was investigated RT-PCR in tumors located at the eye, ear and intraperitoneum of control and HB-19 treated RET mice (as in Figure 5). The eye, ear and intraperitoneal tumors are representative for the firstly diagnosed nodule, a cutaneous nodule and a metastatic nodule, respectively. Equivalent tumor masses at similar locations were considered for comparison.