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Table 1 Chronobiological data derived from best fitting sine curves (fitted period:24 hours = 360°) and F and p value from ANOVA performed between the timepoints for each variable

From: Altered time structure of neuro-endocrine-immune system function in lung cancer patients

Healthy subjects

 

Lung cancer patients

Factor

p#

MESOR ± SE

Amplitude ± SE

Acrophase ± SE

ANOVA

p#

MESOR ± SE

Amplitude ± SE

Acrophase ± SE

ANOVA

     

Original Units

% of mean

    

Original Units

% of mean

     

F

p

F

p

    

F

p

F

p

Cortisol

0.027

12.52 ± 1.53

5.85 ± 1.97

08:08 ± 01:18

6.3

0.01

22.3

<0.01

0.138

17.85 ± 1.03*

4.21 ± 1.39

09:00 ± 01:32

1.1

0.41

5.1

<0.01

Melatonin

0.013

38.75 ± 5.43

26.24 ± 7.32

01:13 ± 01:15

14.2

<0.01

25.4

<0.01

0.036

33.12 ± 7.34

23.12 ± 9.94

01:28 ± 01:37

4.9

<0.01

12.3

<0.01

TRH

0.024

0.45 ± 0.09

0.04 ± 0.05

02:47 ± 01:05

0.1

0.97

4.5

0.01

0.245

0.60 ± 0.02*

0.03 ± 0.04

23:41 ± 01:48

0.3

0.35

0.5

0.46

TSH

0.020

1.38 ± 0.04

0.45 ± 0.03

23:12 ± 00:32

2.3

0.08

12.5

0.01

0.328

1.33 ± 0.09*

0.18 ± 0.08

00:05 ± 02:05

0.6

0.78

3.9

0.01

FT4

0.897

1.24 ± 0.06

0.01 ± 0.03

15:52 ± 08:08

0.3

0.95

1.4

0.15

0.377

1.33 ± 0.02

0.02 ± 0.03

18:44 ± 02:13

0.4

0.96

0.8

0.72

GH

0.039

0.38 ± 0.03

0.45 ± 0.02

00:22 ± 00:50

3.9

0.01

5.8

<0.01

0.447

1.55 ± 0.17*

0.38 ± 0.23

22:16 ± 02:36

0.5

0.61

1.3

0.23

IGF-1

0.578

221.01 ± 6.0

9.34 ± 8.12

08:28 ± 03:24

0.2

0.76

3.4

0.09

0.424

156.02 ± 1.88*

4.05 ± 2.36

02:41 ± 02:26

0.1

0.89

1.7

0.29

CD3

0.014

82.10 ± 0.31

0.98 ± 0.53

03:17 ± 22:09

0.3

0.96

2.3

0.04

0.135

83.01 ± 0.21

1.08 ± 0.25

20:49 ± 01:21

0.7

0.76

1.9

0.21

CD4

0.033

45.12 ± 0.75

3.11 ± 1.02

01:16 ± 01:17

1.5

0.36

4.0

<0.01

0.035

43.83 ± 1.27

6.13 ± 1.47

22:48 ± 00:53

2.3

0.04

6.2

0.01

CD8

0.024

29.61 ± 0.74

2.59 ± 1.04

12:48 ± 01:37

0.4

0.76

4.2

0.01

0.531

23.12 ± 0.36*

0.52 ± 0.46

11:21 ± 03:04

0.4

0.98

0.9

0.61

CD8 Bright

0.039

21.06 ± 0.54

1.35 ± 072

13:34 ± 02:04

0.6

0.84

1.4

0.04

0.597

15.21 ± 0.26*

0.42 ± 0.36

04:45 ± 03:19

0.3

0.93

0.7

0.72

CD8 Dim

0.028

9.22 ± 0.39

1.10 ± 0.49

12:37 ± 01:58

1.5

0.35

3.7

0.01

0.631

9.45 ± 0.43

0.82 ± 0.69

12:46 ± 03:40

0.6

0.62

1.2

0.39

CD16

0.015

7.89 ± 0.21

1.42 ± 0.36

13:24 ± 01:37

0.7

0.51

2.8

0.01

0.187

16.33 ± 0.41*

2.12 ± 0.37

11:16 ± 01:32

0.5

0.81

2.3

0.05

CD20

0.006

11.21 ± 0.04

1.21 ± 0.08

21:24 ± 00:21

0.4

0.98

2.3

0.09

0.129

8.73 ± 0.12

0.61 ± 0.45

02:21 ± 01:16

0.3

0.89

1.0

0.56

CD25

0.040

5.52 ± 0.12

0.44 ± 0.19

19:46 ± 01:34

0.2

0.93

2.4

0.08

0.526

7.02 ± 0.31

0.68 ± 0.32

20:12 ± 03:04

0.6

0.80

3.9

<0.01

HLA-DR

0.033

15.28 ± 0.39

0.69 ± 0.56

22:33 ± 03:21

0.6

0.67

2.2

0.07

0.893

14.02 ± 0.41

0.28 ± 0.49

18:47 ± 08:06

0.1

0.54

0.5

0.83

TcR δ 1

0.026

3.59 ± 0.11

0.41 ± 0.18

11:12 ± 01:33

0.2

0.89

3.2

0.04

0.082

2.24 ± 0.02*

0.94 ± 0.15

14:09 ± 00:22

1.2

0.39

3.6

0.01

δTcS1

0.036

1.43 ± 0.05

0.43 ± 0.06

10:52 ± 00:44

0.4

0.76

2.9

0.03

0.918

0.91 ± 0.20*

0.07 ± 0.18

14:56 ± 09:32

0.2

0.78

2.1.

0.08

IL-2

0.424

0.43 ± 0.02

0.05 ± 0.03

14:53 ± 02:32

0.2

0.98

0.3

0.94

0.627

0.52 ± 0.03*

0.02 ± 0.04

17:01 ± 03:10

0.4

0.86

1.0

0.05

  1. Units: μg/dl for cortisol, pg/ml for melatonin, ng/ml for TRH, μU/ml for TSH, ng/dl for FT4, ng/ml for GH, ng/ml for IGF-I, percentage for lymphocyte subpopulations, IU/ml for IL-2; all parameters analyzed in all the subjects; Hr:Mn for acrophase; all parameters analyzed in all the subjects. # p value from an F-test of the null amplitude rejection hypothesis (for a rhythm with a chosen period τ); * p value < 0.05 from t-test or Mann-Whitney rank sum test as indicated performed on MESOR, amplitude and acrophase values
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BMC Cancer

ISSN: 1471-2407

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