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Table 5 Relations between CYP2C19, CYP2D6, CYP3A5 and SULT1A1 genotypes and estrogens in postmenopausal women (n = 90)

From: Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

   

Median concentration [q1 - q3] 1

Genotype (n)

E1

E2

E1S

CYP2C192

*2/*2

(4)

122 [88 - 303]

9.6 [6.7 - 43.5]

857 [309 - 1400]

 

*1/*2

(15)

106 [72 - 182]

13.0 [6.6 - 32.0]

391 [234 - 955]

 

*1/*1

(35)

102 [70 - 124]

10.9 [5.7 - 16.0]

655 [345 - 928]

 

Vt*17

(33)

86 [66 - 104]

8.4 [6.0 - 12.1]

545 [259 - 801]

 

*17/*17

(3)

75 [54 - 122]

9.3 [9.3 - 17.4]

428 [158 - 654]

P3

  

0.019*

0.139

0.227

CYP2D64

PM

(6)

111 [96 - 154]

9.4 [6.6 - 24.4]

491 [318 - 878]

 

IM

(32)

91 [66 - 111]

7.7 [5.2 - 14.1]

595 [255 - 931]

 

Wt/Wt

(51)

101 [67 - 128]

10.9 [6.1 - 17.4]

588 [345 - 888]

 

UM

(1)

72

6.6

391

P

  

0.559

0.938

0.804

CYP3A5

Vt/Vt

(76)

99 [71 - 123]

10.5 [6.6 - 16.4]

569 [305 - 865]

 

Wt/Vt

(14)

97 [65 - 124]

8.0 [4.3 - 10.5]

631 [294 - 1127]

P

  

0.520

0.248

0.221

SULT1A1

Vt/Vt

(14)

80.6 [66.4- 103.5]

6.7 [5.2- 9.4]

590.4 [316.5- 851.1]

 

Wt/Vt

(32)

99.1 [68.6-121.7]

13.7 [5.3-18.9]

537.0 [318.0- 768.7]

 

Wt/Wt

(44)

102.1 [70.9-142.1]

9.4 [1.4-54.7]

608.5 [135.6-2922.9]

P

  

0.280

0.575

0.734

SULT1A1copy numbers

1

(3)

59.7 [58.7-101.2]

3.8 [2.6- 6.5]

252.9 [235.5- 939.0]

 

2

(59)

89.8 [67.2-110.2]

7.7 [5.5-15.2]

498.4 [271.6- 758.9]

 

3

(21)

105.7 [90.7-128.6]

11.8 [9.0-14.3]

859.5 [561.3- 955.2]

 

4

(5)

101.8 [98.0- 103.0]

15.3 [12.6-19.1]

363.6 [227.5- 662.0]

 

5

(2)

157.6 [155.3-160.0]

13.6 [9.4-17.9]

2086.3 [1780.7-2391.9]

P

  

0.024*

0.010*

0.005**

  1. 1Median concentration [quartile 1 - quartile 3] values of tamoxifen and metabolites are given as ng/ml.
  2. 2*2/*2, encodes defective CYP2C19 activity; Vt*17, subjects heterozygous for the variant type allele CYP2C19*17 (*1/*17 and *2/*17); *17/*17, encodes ultra rapid CYP2C19 activity.
  3. 3P values were calculated by multivariate logistic regression model, *p < 0.05. Adjusted for CYP2C19, CYP2D6, CYP3A5, SULT1A1, SULT1A1 copy number, FSH and SHBG.
  4. 4PM, poor metabolizer; IM, wild type/variant type; Wt/Wt, wild type/wild type; UM, ultra rapid metabolizer.
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BMC Cancer

ISSN: 1471-2407

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