| | | |
Median concentration [q1 - q3] 1
|
|---|
|
Genotype (n)
|
E1
|
E2
|
E1S
|
|---|
|
CYP2C192
|
*2/*2
|
(4)
|
122 [88 - 303]
|
9.6 [6.7 - 43.5]
|
857 [309 - 1400]
|
| |
*1/*2
|
(15)
|
106 [72 - 182]
|
13.0 [6.6 - 32.0]
|
391 [234 - 955]
|
| |
*1/*1
|
(35)
|
102 [70 - 124]
|
10.9 [5.7 - 16.0]
|
655 [345 - 928]
|
| |
Vt*17
|
(33)
|
86 [66 - 104]
|
8.4 [6.0 - 12.1]
|
545 [259 - 801]
|
| |
*17/*17
|
(3)
|
75 [54 - 122]
|
9.3 [9.3 - 17.4]
|
428 [158 - 654]
|
|
P3
| | |
0.019*
|
0.139
|
0.227
|
|
CYP2D64
|
PM
|
(6)
|
111 [96 - 154]
|
9.4 [6.6 - 24.4]
|
491 [318 - 878]
|
| |
IM
|
(32)
|
91 [66 - 111]
|
7.7 [5.2 - 14.1]
|
595 [255 - 931]
|
| |
Wt/Wt
|
(51)
|
101 [67 - 128]
|
10.9 [6.1 - 17.4]
|
588 [345 - 888]
|
| |
UM
|
(1)
|
72
|
6.6
|
391
|
|
P
| | |
0.559
|
0.938
|
0.804
|
|
CYP3A5
|
Vt/Vt
|
(76)
|
99 [71 - 123]
|
10.5 [6.6 - 16.4]
|
569 [305 - 865]
|
| |
Wt/Vt
|
(14)
|
97 [65 - 124]
|
8.0 [4.3 - 10.5]
|
631 [294 - 1127]
|
|
P
| | |
0.520
|
0.248
|
0.221
|
|
SULT1A1
|
Vt/Vt
|
(14)
|
80.6 [66.4- 103.5]
|
6.7 [5.2- 9.4]
|
590.4 [316.5- 851.1]
|
| |
Wt/Vt
|
(32)
|
99.1 [68.6-121.7]
|
13.7 [5.3-18.9]
|
537.0 [318.0- 768.7]
|
| |
Wt/Wt
|
(44)
|
102.1 [70.9-142.1]
|
9.4 [1.4-54.7]
|
608.5 [135.6-2922.9]
|
|
P
| | |
0.280
|
0.575
|
0.734
|
|
SULT1A1copy numbers
|
1
|
(3)
|
59.7 [58.7-101.2]
|
3.8 [2.6- 6.5]
|
252.9 [235.5- 939.0]
|
| |
2
|
(59)
|
89.8 [67.2-110.2]
|
7.7 [5.5-15.2]
|
498.4 [271.6- 758.9]
|
| |
3
|
(21)
|
105.7 [90.7-128.6]
|
11.8 [9.0-14.3]
|
859.5 [561.3- 955.2]
|
| |
4
|
(5)
|
101.8 [98.0- 103.0]
|
15.3 [12.6-19.1]
|
363.6 [227.5- 662.0]
|
| |
5
|
(2)
|
157.6 [155.3-160.0]
|
13.6 [9.4-17.9]
|
2086.3 [1780.7-2391.9]
|
|
P
| | |
0.024*
|
0.010*
|
0.005**
|
-
1Median concentration [quartile 1 - quartile 3] values of tamoxifen and metabolites are given as ng/ml.
-
2*2/*2, encodes defective CYP2C19 activity; Vt*17, subjects heterozygous for the variant type allele CYP2C19*17 (*1/*17 and *2/*17); *17/*17, encodes ultra rapid CYP2C19 activity.
-
3P values were calculated by multivariate logistic regression model, *p < 0.05. Adjusted for CYP2C19, CYP2D6, CYP3A5, SULT1A1, SULT1A1 copy number, FSH and SHBG.
-
4PM, poor metabolizer; IM, wild type/variant type; Wt/Wt, wild type/wild type; UM, ultra rapid metabolizer.
