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Table 5 Relations between CYP2C19, CYP2D6, CYP3A5 and SULT1A1 genotypes and estrogens in postmenopausal women (n = 90)

From: Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

    Median concentration [q1 - q3] 1
Genotype (n) E1 E2 E1S
CYP2C192 *2/*2 (4) 122 [88 - 303] 9.6 [6.7 - 43.5] 857 [309 - 1400]
  *1/*2 (15) 106 [72 - 182] 13.0 [6.6 - 32.0] 391 [234 - 955]
  *1/*1 (35) 102 [70 - 124] 10.9 [5.7 - 16.0] 655 [345 - 928]
  Vt*17 (33) 86 [66 - 104] 8.4 [6.0 - 12.1] 545 [259 - 801]
  *17/*17 (3) 75 [54 - 122] 9.3 [9.3 - 17.4] 428 [158 - 654]
P3    0.019* 0.139 0.227
CYP2D64 PM (6) 111 [96 - 154] 9.4 [6.6 - 24.4] 491 [318 - 878]
  IM (32) 91 [66 - 111] 7.7 [5.2 - 14.1] 595 [255 - 931]
  Wt/Wt (51) 101 [67 - 128] 10.9 [6.1 - 17.4] 588 [345 - 888]
  UM (1) 72 6.6 391
P    0.559 0.938 0.804
CYP3A5 Vt/Vt (76) 99 [71 - 123] 10.5 [6.6 - 16.4] 569 [305 - 865]
  Wt/Vt (14) 97 [65 - 124] 8.0 [4.3 - 10.5] 631 [294 - 1127]
P    0.520 0.248 0.221
SULT1A1 Vt/Vt (14) 80.6 [66.4- 103.5] 6.7 [5.2- 9.4] 590.4 [316.5- 851.1]
  Wt/Vt (32) 99.1 [68.6-121.7] 13.7 [5.3-18.9] 537.0 [318.0- 768.7]
  Wt/Wt (44) 102.1 [70.9-142.1] 9.4 [1.4-54.7] 608.5 [135.6-2922.9]
P    0.280 0.575 0.734
SULT1A1copy numbers 1 (3) 59.7 [58.7-101.2] 3.8 [2.6- 6.5] 252.9 [235.5- 939.0]
  2 (59) 89.8 [67.2-110.2] 7.7 [5.5-15.2] 498.4 [271.6- 758.9]
  3 (21) 105.7 [90.7-128.6] 11.8 [9.0-14.3] 859.5 [561.3- 955.2]
  4 (5) 101.8 [98.0- 103.0] 15.3 [12.6-19.1] 363.6 [227.5- 662.0]
  5 (2) 157.6 [155.3-160.0] 13.6 [9.4-17.9] 2086.3 [1780.7-2391.9]
P    0.024* 0.010* 0.005**
  1. 1Median concentration [quartile 1 - quartile 3] values of tamoxifen and metabolites are given as ng/ml.
  2. 2*2/*2, encodes defective CYP2C19 activity; Vt*17, subjects heterozygous for the variant type allele CYP2C19*17 (*1/*17 and *2/*17); *17/*17, encodes ultra rapid CYP2C19 activity.
  3. 3P values were calculated by multivariate logistic regression model, *p < 0.05. Adjusted for CYP2C19, CYP2D6, CYP3A5, SULT1A1, SULT1A1 copy number, FSH and SHBG.
  4. 4PM, poor metabolizer; IM, wild type/variant type; Wt/Wt, wild type/wild type; UM, ultra rapid metabolizer.