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Table 3 Associations between the serum concentrations of tamoxifen, estrogens, FSH1, and SHBG

From: Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer

Variables Tamoxifen 4OHtam 4OHNDtam NDtam NDDtam TamNox SHBG
All (n = 90) r r r r r r r
E2 0.295* 0.131 0.211 0.148 0.315** 0.232 -0.048
E1 0.297* 0.133 0.152 0.226 0.330** 0.292* -0.002
E1S 0.254 0.119 0.118 0.247 0.194 0.284* -0.445**
FSH 0.118 0.065 0.269* 0.134 0.031 0.178 0.095
SHBG -0.027 0.034 0.088 0.000 0.048 0.103  
Wt/Wt EM CYP2D6 (n = 51)        
FSH 0.151 0.133 0.386* 0.148 0.133 0.259 0.224
  1. 1FSH, Follicle Stimulating Hormone; SHBG, sex hormone binding globulin; 4OHtam, 4-hydroxytamoxifen; 4OHNDtam, 4-hydroxy-N-demethyltamoxifen; NDtam, N-demethyltamoxifen; NDDtam, N-dedimethyltamoxifen; tamNox, tamoxifen-N-oxide; r, coefficient; E2, estradiol; E1, estrone; E1S, estrone sulfate; Wt/Wt EM, wild type/wild type extensive metabolizer CYP2D6.
  2. r and p values are derived from two-tailed Spearman correlation rank test. The p-values are given after Bonferroni correction for multiple (n = 5) comparisons within this data set, *p < 0.05, and **p < 0.01.