Subgroup | D1 surgery | D3 surgery | HR (95% CI) | P |
---|---|---|---|---|
 | No. of deaths/no. of patients |  |  | |
Total | 150/187 | 137/191 | 1.407(1.113-1.779) | Â |
Age (years) | Â | Â | Â | Â |
   ≤55 | 49/66 | 70/107 | 1.384(0.955-2.004) | 0.086 |
   >55 | 101/121 | 67/84 | 1.242(0.911-1.693) | 0.170 |
Sex | Â | Â | Â | Â |
   Women | 41/51 | 44/58 | 1.248(0.815-1.912) | 0.309 |
   Men | 109/136 | 93/133 | 1.463(1.103-1.939) | 0.008* |
Tumor size | Â | Â | Â | Â |
   ≤5 | 91/125 | 74/113 | 1.401(1.028-1.910) | 0.033* |
   5-7 | 30/32 | 42/50 | 1.412(0.875-2.279) | 0.158 |
   >7 | 29/30 | 21/28 | 1.917(1.075-3.419) | 0.027* |
Tumour site | Â | Â | Â | Â |
   Upper stomach | 40/44 | 37/42 | 1.116(0.707-1.762) | 0.638 |
   Middle stomach | 35/43 | 29/45 | 1.641(0.984-2.735) | 0.058 |
   Lower stomach | 64/88 | 59/90 | 1.482(1.038-2.117) | 0.030* |
   Whole stomach | 11/12 | 12/14 | 1.574(0.685-3.618) | 0.286 |
Gross appearance | Â | Â | Â | Â |
   Borrmann types I | 37/58 | 35/54 | 1.100(0.688-1.759) | 0.691 |
   Borrmann types II | 33/41 | 32/43 | 1.781(1.069-2.967) | 0.027* |
   Borrmann types III | 66/73 | 56/77 | 1.685(1.175-2.416) | 0.005* |
   Borrmann types IV | 14/15 | 14/17 | 1.708(0.810-3.600) | 0.160 |
Tumour stage | Â | Â | Â | Â |
   T1 | 29/41 | 24/44 | 1.723(0.992-2.992) | 0.054 |
   T2 | 30/44 | 29/42 | 1.282(0.754-2.178) | 0.359 |
   T3 | 79/89 | 71/92 | 1.431(1.037-1.977) | 0.029* |
   T4 | 12/13 | 13/13 | 1.071(0.485-2.365) | 0.866 |
Clinical node status | Â | Â | Â | Â |
   Negative | 4/5 | 2/5 | 3.070(0.533-17.703) | 0.209 |
   Positive | 146/182 | 135/186 | 1.382(1.091-1.752) | 0.007* |
Lymph-node stage | Â | Â | Â | Â |
   N0 | 50/69 | 42/69 | 1.781(1.168-2.718) | 0.007* |
   N1 | 64/75 | 60/81 | 1.504(1.055-2.145) | 0.024* |
   N2 | 24/30 | 19/24 | 1.116(0.609-2.044) | 0.723 |
   N3 | 12/13 | 16/17 | 0.369(0.162-0.841)†| 0.018* |
Histological type | Â | Â | Â | Â |
   Differentiated | 62/99 | 49/82 | 1.143(0.761-1.563) | 0.231 |
   Undifferentiated | 62/99 50/88 | 49/82 56/109 | 1.047(0.773-1.732) | 0.334 |
Joint organ removal | Â | Â | Â | Â |
   None | 127/160 | 104/157 | 1.703(1.309-2.217) | 0.000* |
   Pancreas or spleen | 6/7 | 14/14 | 0.754(0.285-1.996) | 0.569 |
   Liver or gall | 9/11 | 9/9 | 0.532(0.200-1.415) | 0.206 |
   Transverse colon | 8/9 | 10/11 | 0.403(0.144-1.133) | 0.085 |
Gastrectomy | Â | Â | Â | Â |
   Total | 20/22 | 26/29 | 1.259(0.697-2.274) | 0.444 |
   Subtotal | 130/165 | 111/162 | 1.495(1.156-1.932) | 0.002* |
Blood transfusion | Â | Â | Â | Â |
   No | 63/87 | 52/80 | 1.316(0.909-1.906) | 0.146 |
   Yes | 87/100 | 85/111 | 1.485(1.097-2.011) | 0.011* |
Blood loss | Â | Â | Â | Â |
   ≤200 | 41/54 | 41/49 | 0.858(0.555-1.328) | 0.493 |
   200-400 | 68/88 | 56/83 | 1.623(1.130-2.332) | 0.009* |
   >400 | 41/45 | 40/59 | 2.060(1.327-3.198) | 0.001* |