Table 3 Associations between HIF-1α staining pattern, clinicopathological features and expression of CAIX, Glut-1 and p27kip1.
Perinecrotic HIF-1α | ||||
|---|---|---|---|---|
Yes (%) | No (%) | P-value | ||
Stage | I | 30 (56) | 24 (44) | |
II | 12 (57) | 9 (43) | 0.845 | |
III | 9 (69) | 4 (31) | ||
IV | 3 (60) | 2 (40) | ||
Grade | 1 | 9 (32) | 19 (68) | |
2 | 33 (70) | 14 (30) | 0.004 | |
3 | 12 (67) | 6 (33) | ||
Myometrial Invasion | 0 | 0 | 3 (100) | |
<50% | 29 (58) | 21 (42) | 0.107 | |
>50% | 25 (63) | 15 (37) | ||
Necrosis | Yes | 54 (77) | 16 (23) | <0.0001 |
No | 0 | 23 (100) | ||
Recurrence/Metastasis | Yes | 14 (79) | 4 (22) | 0.043 |
No | 37 (51) | 35 (49) | ||
p27kip1 | Pos | 48 (89) | 38 (97) | 0.125 |
Neg | 6 (11) | 1 (3) | ||
p27kip1 | ≤50% | 48 (58) | 35 (42) | 0.896 |
>50% | 6 (60) | 4 (40) | ||
p27kip1 expression pattern | Peri/central | 30(91) | 3(9) | <0.0 |
Other* | 24(40) | 36(60) | 001 | |
CAIX | Pos | 47 (67) | 24 (33) | 0.004 |
Neg | 7 (32) | 15 (68) | ||
Glut-1 | Pos | 48 (63) | 28 (37) | 0.035 |
Neg | 6 (35) | 11 (65) | ||
CAIX and Glut-1 | Pos | 42 (68) | 20 (32) | 0.007 |
Neg | 12 (39) | 19 (61) | ||