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Table 3 Associations between HIF-1α staining pattern, clinicopathological features and expression of CAIX, Glut-1 and p27kip1.

From: Necrosis related HIF-1α expression predicts prognosis in patients with endometrioid endometrial carcinoma

Perinecrotic HIF-1α
   Yes (%) No (%) P-value
Stage I 30 (56) 24 (44)  
  II 12 (57) 9 (43) 0.845
  III 9 (69) 4 (31)  
  IV 3 (60) 2 (40)  
Grade 1 9 (32) 19 (68)  
  2 33 (70) 14 (30) 0.004
  3 12 (67) 6 (33)  
Myometrial Invasion 0 0 3 (100)  
  <50% 29 (58) 21 (42) 0.107
  >50% 25 (63) 15 (37)  
Necrosis Yes 54 (77) 16 (23) <0.0001
  No 0 23 (100)  
Recurrence/Metastasis Yes 14 (79) 4 (22) 0.043
  No 37 (51) 35 (49)  
p27kip1 Pos 48 (89) 38 (97) 0.125
  Neg 6 (11) 1 (3)  
p27kip1 ≤50% 48 (58) 35 (42) 0.896
  >50% 6 (60) 4 (40)  
p27kip1 expression pattern Peri/central 30(91) 3(9) <0.0
  Other* 24(40) 36(60) 001
CAIX Pos 47 (67) 24 (33) 0.004
  Neg 7 (32) 15 (68)  
Glut-1 Pos 48 (63) 28 (37) 0.035
  Neg 6 (35) 11 (65)  
CAIX and Glut-1 Pos 42 (68) 20 (32) 0.007
  Neg 12 (39) 19 (61)  
  1. HIF-1α = hypoxia-inducible factor 1α; CAIX = carbonic anhydrase IX; Glut-1 = glucose transporter 1, * other staining patterns include diffuse staining or negative for p27kip1.