Figure 7
Inhibition of extracellular hsp90α inhibits cancer cell motility by preventing plasmin activation. HT-1080 cells were treated with control, IgG, plasmin, anti-hsp90α antibody, or plasmin plus anti-hsp90α antibody. A transwell migration assay was performed and cells that migrated through the chamber were counted. Results are from four independent experiments and expressed as percentage decrease from control (100%). Anti-hsp90α antibody results in a 37% decrease in migration (p < 0.01, two tailed t test).