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Table 5 The association between family history of previous cancer and risk of lung cancer in a population based case-control study, Greater Toronto Area, Ontario, 1997-2002

From: Lung cancer risk in never-smokers: a population-based case-control study of epidemiologic risk factors

  Total Population n = 1393   Never smokers n = 622  
  Case, n Control, n ORa 95%CI Case, n Control, n ORb 95%CI
  445 948    156 466   
No family history of any cancer 246 563 1.0 Refc 95 293 1.0 Refd
Positive family history of any cancer         
   1 141 292 1.1 0.8-1.4 42 134 0.9 0.6-1.4
   2 or more 58 93 1.3 0.9-1.9 19 39 1.4 0.8-2.8
   Affected relatives age at onset < 50 82 126 1.3 0.9-1.9 28 48 1.8 1.0-3.2
Positive family history of aero-digestive cancer 45 78 1.2 0.8-1.8 11 34 0.9 0.4-1.9
Positive family history of lung cancer 30 63 1.0 0.6-1.7 8 26 0.9 0.4-2.1
  1. aAdjusted for pack-years smoking, age, sex, education and ethnicity
  2. bAdjusted for age, sex, education and ethnicity
  3. cReference group consists of all participants with no family history of cancer
  4. dReference group consists of never smokers with no family history of cancer