Combined effects of IL-8 and CXCR2gene polymorphisms on breast cancer susceptibility and aggressiveness

BMC Cancer

Table 6 Genotype frequencies of IL-8 (-251) T/A polymorphism in relation to pathological indices of Breast Cancer severity

Genotypes	Number of patients (%)		Crude OR (95% CI)	P-value^a	Adjusted OR (95% CI)^b	P-value
Clinical tumor size	T1-T2	T3-T4
TT	65 (27.08)	37 (24.51)	1		1
TA	122 (50.84)	58 (38.41)	0.84 [0.49-1.44]	0.48	0.74 [0.67-1.32]	0.87
AA	53 (22.08)	56 (37.08)	1.86 [1.03-3.35]	0.02	1.79 [1.11-3.76]	0.01
Alleles
T-allele	252 (52.50)	132 (43.71)
A-allele	228 (47.50)	170 (56.29)	1.42 [1.05-1.92]	0.01	1.57 [1.32-2.05]	0.01
Lymph nodes status	Negative	Positive
TT	50 (27.62)	42 (19.91)	1		1
TA	92 (50.83)	95 (45.02)	1.46 [0.85-2.52]	0.14	1.32 [0.78-2.01]	0.21
AA	39 (21.55)	74 (35.07)	2.26 [1.24-4.14]	0.004	2.59 [1.47-5.32]	0.002
Alleles
T-allele	192 (53.04)	179 (42.42)
A-allele	170 (46.96)	243 (57.58)	1.53 [1.14-2.05]	0.002	1.58 [1.28-2.24]	0.001
SBR grading	1-2	3
TT	66 (32.19)	46 (28.22)	1		1
TA	111 (54.15)	67 (41.11)	0.87 [0.52-1.45]	0.55	0.91 [0.58-1.49]	0.34
AA	28 (13.66)	50 (30.67)	2.56 [1.35-4.87]	0.001	2.69 [1.52-5.24]	0.0009
Alleles
T-allele	243 (59.27)	159 (48.77)
A-allele	167 (40.73)	167 (51.23)	1.53 [1.13-2.07]	0.004	1.66 [1.38-2.79]	0.002
Estrogen receptor status	Negative	Positive
TT	41 (23.7)	51 (41.13)	1		1
TA	75 (43.35)	44 (35.48)	2.12 [1.17-3.84]	0.007	2.01 [1.32-3.76]	0.006
AA	57 (32.95)	29 (23.39)	2.44 [1.28-4.70]	0.003	2.56 [1.68-4.96]	0.001
Alleles
T-allele	157 (45.38)	146 (58.87)
A-allele	189 (54.62)	102 (41.13)	1.72 [1.22-2.48]	0.001	1.82 [1.96-2.78]	0.0008

^a P-value determined by χ² test.
^b ORs were adjusted for age, BMI, history of benign disease, and oral contraceptive drugs usage.

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