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Table 5 Interaction and addictive effects of IL-8 (-251) T/A and CXCR2 (+1208) C/T polymorphisms on breast cancer risk

From: Combined effects of IL-8 and CXCR2gene polymorphisms on breast cancer susceptibility and aggressiveness

Genotypes

Patients (n = 409)

Controls (n = 301)

Crude OR (95% CI)

P-valuea

Adjusted OR (95%)b

P-value

IL-8 (-251) /CXCR2 (+1208)

n %

n %

    

0

75 (18.34)

81 (26.91)

1

 

1

 

1

293 (71.64)

206 (68.44)

1.54 [1.05-2.24]

0.01

1.63 [1.13-2.59]

0.01

2

41 (10.02)

14 (4.65)

3.16 [1.52-6.64]

0.0006

4.15 [1.92-7.32]

0.0004

  1. a P-value determined by χ2 test.
  2. b ORs were adjusted for age, BMI, history of benign disease, and oral contraceptive drugs usage.
  3. The high risk genotypes: IL-8 (-251) T/A = TA/AA; CXCR2 (+1208) C/T = TT
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BMC Cancer

ISSN: 1471-2407

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