Combined effects of IL-8 and CXCR2gene polymorphisms on breast cancer susceptibility and aggressiveness

BMC Cancer

Table 4 The IL-8 (-251) T/A and CXCR2 (+1208) C/T genotype distributions in Control Subjects and in Patients with Breast Carcinoma

Genotypes	Patients (n = 409)	Controls (n = 301)	Crude OR (95% CI)	P-value^a	Adjusted OR (95% CI)^b	P-value
	n (%)	n (%)
*IL-8* (-251)T/A
TT	84 (20.5)	92 (30.6)	1		1
TA	201 (49.2)	138 (45.8)	1.60 [1.09-2.34]	0.01	1.71 [1.13-2.55]	0.009
AA	124 (30.3)	71 (23.6)	1.91 [1.24-2.96]	0.002	2.03 [1.56-3.67]	0.001
Alleles
T-allele	369 (45.1)	322 (53.5)
A-allele	449 (54.9)	280 (46.5)	1.40 [1.13-1.74]	0.001	1.86 [1.79-2.45]	0.001
*CXCR2* (+1208)C/T
CC	195 (46.7)	155 (51.5)	1		1
CT	167 (40.8)	128 (42.5)	1.04 [0.75-1.43]	0.81	1.31 [0.90-1.69]	0.63
TT	47 (11.5)	18 (6.0)	2.08 [1.12-3.88]	0.01	2.89 [1.48-4.55]	0.008
Alleles
C-allele	557 (6.81)	438 (7.28)
T-allele	261 (31.9)	164 (27.2)	1.25 [0.99-1.59]	0.05	1.37 [1.09-1.88]	0.03

^a P-value determined by χ² test.
^b ORs were adjusted for age, BMI, history of benign disease, and oral contraceptive drugs usage.

ISSN: 1471-2407