Figure 6
From: Quercetin abrogates chemoresistance in melanoma cells by modulating ΔNp73
Knockdown of p73 with siRNA restores PARP cleavage. Western blot analysis after transfection with p73 siRNA in DB-1 cell lines A) at basal level and B) after TMZ treatment and C) Quantification of p73 to GAPDH and Cleaved PARP relative to uncleaved PARP. D) Transient transfection of tyrosinase DNA in DB-1 cell lines and western blot analysis of p53 and 73 expression.