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Table 5 Association statistics for CCR2-V64I genotypes for HSIL in the control group

From: CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

 

Normal cytology (n = 1070)

HSIL positive (n = 45)

  
 

Black 210 (20)

Mixed-ancestry 860 (80)

Black 16 (36)

Mixed-ancestry 29 (64)

Genotype-HSIL association, adjusted for ethnicity and smoking

Genotypes

n (%)

n (%)

n (%)

n (%)

P-value

OR (95% CI)

CCR2 G→A

     

GG

124 (59)

563 (66)

12 (75)

21 (72)

-

1

AG

84 (40)

287 (33)

4 (25)

8 (28)

0.190

0.64 (0.32-1.25)

AA

2 (1)

10 (1)

0 (0)

0 (0)

-

-

AG + AA

86 (41)

297 (35)

4 (30)

8 (28)

0.157

0.61 (0.31-1.21)

  1. HSIL positive = Positive for HSIL by pap smear test, Normal cytology = Negative for pap smear test.