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Table 2 Association statistics for CCR2-V64I genotypes for cases and SIL positive controls

From: CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women

 

SIL positive controls (n = 91)

Cases (n = 446)

  
 

Black 31 (34)

Mixed-ancestry 60 (66)

Black 106 (24)

Mixed-ancestry 340 (76)

Genotype-cervical cancer association, adjusted for ethnicity and smoking

Genotypes

n (%)

n (%)

n (%)

n (%)

P-value

OR (95% CI)

CCR2 G→A

     

GG

21 (68)

40 (66)

24 (23)

78 (23)

-

1

AG

9 (29)

19 (32)

81 (76)

255 (75)

0.001

7.18 (4.35-11.87)

AA

1 (3)

1 (2)

1 (1)

7 (2)

0.300

2.32 (0.47-11.36)

AG + AA

10 (32)

20 (33)

82 (77)

262 (77)

0.001

6.86 (4.19-11.21)

  1. Cases = Women with cancer of the cervix (ICC), SIL positive controls = Women without cancer of the cervix (ICC) but positive for LSIL and HSIL by pap smear test.