Table 2 Risk of colorectal cancer in relation to selected genetic polymorphisms
| Â | Number (%) | Â | |
|---|---|---|---|
Genotype | Cases, n = 685 | Controls, n = 778 | OR (95% CI)* |
CYP1A1*2A | Â | Â | Â |
   0†| 283 (41.3) | 305 (39.2) | 1.00 (referent) |
   1 | 307 (44.8) | 368 (47.3) | 0.90 (0.72-1.13) |
   2 | 95 (13.9) | 105 (13.5) | 0.97 (0.70-1.35) |
CYP1A1*2C | Â | Â | Â |
   0†| 418 (61.0) | 461 (59.3) | 1.00 (referent) |
   1 | 231 (33.7) | 276 (35.5) | 0.94 (0.75-1.17) |
   2 | 36 (5.3) | 41 (5.3) | 1.00 (0.62-1.62) |
GSTM1 | Â | Â | Â |
   Non-null | 328 (47.9) | 356 (45.8) | 1.00 (referent) |
   Null | 357 (52.1) | 422 (54.2) | 0.90 (0.73-1.11) |
GSTT1 | Â | Â | Â |
   Non-null | 347 (50.7) | 435 (55.9) | 1.00 (referent) |
   Null | 338 (49.3) | 343 (44.1) | 1.20 (0.97-1.48) |
GSTM1 + GSTT1 | Â | Â | Â |
   Non-null | 502 (73.3) | 589 (75.7) | 1.00 (referent) |
   Null | 183 (26.7) | 189 (24.3) | 1.09 (0.86-1.39) |
NQO1 Pro187Ser‡ |  |  |  |
   Pro/Pro | 259 (37.9) | 282 (36.3) | 1.00 (referent) |
   Pro/Ser | 336 (49.1) | 392 (50.5) | 0.94 (0.75-1.18) |
   Ser/Ser | 89 (13.0) | 103 (13.3) | 0.97 (0.69-1.35) |