Table 1 Genes differentially expressed in at least four out of the seven MTX-resistant cell lines studied.
From: Overexpression of S100A4 in human cancer cell lines resistant to methotrexate
Genbank | Gene Name | Description | Fold Change | ||||||
|---|---|---|---|---|---|---|---|---|---|
HT29 | Caco-2 | MCF-7 | MDA- MB-468 | MIA PaCa-2 | K562 | SaOs-2 | |||
U05598 | AKR1C2 | aldo-keto reductase family 1, member C2 | 4.6 | 10.2 | 0.03 | 31.1 | 0.02 | 5.0 | NS |
AB018580 | AKR1C3 | aldo-keto reductase family 1, member C3 | 1.8 | 4.6 | 0.8 | 73.3 | 0.7 | 12.0 | NS |
NM_000691 | ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 2.9 | 3.8 | 6.6 | 11.9 | 0.4 | NS | NS |
AL136912 | ATG10 | ATG10 autophagy related 10 homolog | 8.7 | NS | NS | 1.5 | 2.1 | 10.1 | 2.0 |
U36190 | CRIP2 | cysteine-rich protein 2 | 2.7 | 1.3 | 1.9 | NS | 2.2 | NS | 0.3 |
NM_001321 | CSRP2 | cysteine and glycine-rich protein 2 | 2.0 | 0.3 | 2.7 | NS | 2.0 | 2.9 | 0.5 |
AU144855 | CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 3.1 | 2.3 | 0.5 | NS | 4.2 | NS | 0.4 |
AI144299 | DHFR | dihydrofolate reductase | 7.3 | 50.2 | 52.8 | 1.8 | 16.9 | 17.8 | 8.9 |
AA578546 | DHFRL1 | dihydrofolate reductase-like 1 | 7.0 | 10.8 | 5.5 | NS | 3.0 | 17.5 | 2.1 |
NM_012242 | DKK1 | dickkopf homolog 1 (Xenopus laevis) | 4.3 | 2.5 | 2.1 | NS | 0.7 | NS | 19.1 |
AI745624 | ELL2 | elongation factor, RNA polymerase II, 2 | NS | 1.7 | 0.4 | 2.6 | 8.0 | 2.3 | 2.7 |
AF052094 | EPAS1 | endothelial PAS domain protein 1 | 2.8 | NS | 2.4 | NS | 6.4 | 0.4 | 0.1 |
AU144565 | EPB41L4A | erythrocyte membrane protein band 4.1 like 4A | 1.6 | 1.3 | 1.7 | 1.4 | 2.3 | 4.4 | 4.7 |
AW246673 | FAM46A | family with sequence similarity 46, member A | NS | 2.6 | NS | NS | 3.9 | 2.5 | 1.5 |
NM_000142 | FGFR3 | fibroblast growth factor receptor 3 | NS | 4.6 | 3.1 | 0.4 | 1.5 | 0.4 | 3.4 |
NM_018071 | FLJ10357 | hypothetical protein FLJ10357 | NS | 3.8 | NS | NS | 2.1 | 3.2 | 3.5 |
BE550452 | HOMER1 | homer homolog 1 (Drosophila) | NS | NS | 27.9 | NS | 2.4 | 13.8 | NS |
AF243527 | KLK5 | kallikrein-related peptidase 5 | 2.3 | NS | 2.2 | NS | 3.5 | NS | 4.6 |
AK022625 | LOC92270 | V-type proton ATPase subunit S1-like protein | 54.0 | 2.3 | NS | NS | 3.4 | 25.0 | NS |
BC006471 | MLLT11 | myeloid/lymphoid or mixed-lineage leukemia | 2.2 | 2.6 | NS | NS | 1.8 | 0.08 | 1.7 |
NM_002439 | MSH3 | mutS homolog 3 (E. coli) | 6.3 | 8.2 | 3,8 | NS | 13.2 | 35.9 | 1,5 |
NM_006117 | PECI | peroxisomal D3, D2-enoyl-CoA isomerase | 7.5 | 2.6 | 1.9 | NS | NS | NS | 1.8 |
BF432873 | PSMD11 | proteasome 26 S subunit, non-ATPase, 11 | NS | 2.3 | NS | NS | 1.3 | 3.5 | 1.4 |
NM_002923 | RGS2 | regulator of G-protein signaling 2, 24 kDa | 1.6 | 8.2 | 3.6 | NS | 3.2 | 1.9 | NS |
AW043594 | RPS23 | ribosomal protein S23 | 12.9 | NS | NS | NS | 2.9 | 8.9 | 1.8 |
NM_005978 | S100A2 | S100 calcium binding protein A2 | 0.5 | 0.3 | 7.1 | NS | 4.0 | NS | 4.1 |
NM_002961 | S100A4 | S100 calcium binding protein A4 | 3.7 | 0.6 | 4.3 | NS | 2.4 | 1.5 | 2.5 |
AL565362 | SLC2A13 | solute carrier family 2, member 13 | 4.0 | 9.4 | 0.6 | 2.5 | 4.3 | 10.2 | NS |
BG150485 | SLC6A6 | solute carrier family 6, member 6 | 0.6 | 2.6 | 2.2 | NS | 2.4 | 1.5 | 1.5 |
NM_003069 | SMARCA1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 1 | 2.6 | 2.6 | 14.0 | NS | NS | 3.4 | 1.7 |
NM_012446 | SSBP2 | single-stranded DNA binding protein 2 | 10.6 | NS | 0.5 | NS | 2.9 | 5.0 | 2.0 |
AW134979 | STXBP6 | syntaxin binding protein 6 (amisyn) | NS | 2.1 | 27.5 | NS | 3.0 | 14.5 | 0.5 |
NM_003248 | THBS4 | thrombospondin 4 | NS | 12.9 | 9.2 | NS | 15.7 | 4.9 | 0.6 |
BE873420 | UGT1A6 | UDP glucuronosyltransferase 1, polypeptide A6 | NS | 2.8 | 24.4 | 27.9 | 5.3 | NS | NS |
AI922599 | VIM | vimentin | 2.4 | NS | 3.6 | NS | NS | 4.9 | 1.7 |
BE539792 | ZCCHC9 | zinc finger, CCHC domain containing 9 | 8.3 | 1.5 | 0.5 | NS | 6.7 | 7.9 | NS |
BU078629 | ZFYVE16 | zinc finger, FYVE domain containing 16 | 6.1 | 45.8 | 76.4 | NS | 16.5 | 23.1 | 3.2 |