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Figure 6 | BMC Cancer

Figure 6

From: Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivoin mice

Figure 6

fVII targeting improved the effect of VP PDT for the treatment of murine breast cancer EMT6 in female Balb/C mice. Mouse breast cancer EMT6 cells were subcutaneously injected into female 4-6-week-old Balb/c mice (Taconic Farms Inc) with 1 × 106 (A) or 2 × 106 (B) cells per mouse. When the tumour size reached about 100 mm3, the mice were treated as follows. A. fVII-VP tPDT and ntPDT with 2 μM VP and a 689 nm laser for 105 J/cm2 were carried out on days 0, 3, 8, and 11 (arrows). B. fVII-tPDT with a final concentration of 2 or 4 μM VP in mfVII-VP was carried out with a 689 nm laser at 105 J/cm2 on days 0, 4, 6, 9, 13, and 16 (arrows). Control mice were i.v. injected with PBS buffer.

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BMC Cancer

ISSN: 1471-2407

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