Figure 4
From: Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4
Cell viability of MCF7 breast cancer cells following treatment with either AMD3100 or the CXCR4 blocking mAb. Cells were treated with (A) CXCR4 antagonist AMD3100 (0.5 - 100 nM) and (B) the blocking mAb, MAB172 (2.5 - 20 μg/ml) for 24 hrs at 5% CO2 at 37°C. Control IgG2b mAb, MAB004 (10 μg/ml) was used as the control. Data are expressed as the mean ± SD of duplicate samples and are representative of three independent experiments. *p < 0.05 versus (A) culture medium (CM) or (B) control mAb (IgG) treated cells.