Figure 3

Representative images of Nav1.8 immunofluorescence in bilateral DRG from rats of the Walker 256 group, the sham group and the normal group. (A) Ipsilateral and (B) contralateral DRG from a tumor-bearing rat. (C) Ipsilateral and (D) contralateral DRG from a sham rat. (E) Ipsilateral and (F) contralateral DRG from a normal rat. Note that Nav1.8 expression in tumor-bearing rats decreased compared to the normal group, although it is not clear from a simple vision inspection whether expression was lower on the ipsilateral or the contralateral side, highlighting the need for quantitative analysis. Scale bar, 50 μm.