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Figure 2 | BMC Cancer

Figure 2

From: Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells

Figure 2

Regulation of Nav1.8 mRNA and protein levels in bilateral DRG of tumor-bearing and sham rats. (A) Relative quantification (triplicate analysis of 4-6 rats for each time point) by real-time RT-PCR revealed a significant decrease in Nav1.8 mRNA in bilateral DRG of tumor-bearing rats compared with the sham group. (B) Western blots revealed a significant decrease in bilateral DRG of tumor-bearing rats compared with the sham group. Moreover, Nav1.8 protein expression was significantly downregulated on the ipsilateral side compared with the contralateral side of tumor-bearing rats. Data are expressed as mean ± SD. *P < 0.05 (one-way ANOVA) compared with sham rats.

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BMC Cancer

ISSN: 1471-2407

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