|
Nutrient (unit) Tertiles
|
All or self-report (SR) only
|
Grade II
|
Grade III
|
Grade IV
|
|---|
| | | | | |
(143 cases, 72 deaths)
|
(130 cases, 103 deaths)
|
(475 cases, 473 deaths)
|
|---|
| |
Lower limit
| |
Upper limit
| |
HR
|
95% CI
|
HR
|
95% CI
|
HR
|
95% CI
|
|
Vitamin E (mg)
|
|
T1:
|
0.8
|
to
|
6.4
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
6.5
|
to
|
9.4
| |
1.00
|
(0.44-2.27)
|
1.02
|
(0.60-1.74)
|
1.15
|
(0.89-1.50)
|
|
T3:
|
9.5
|
to
|
42.1
| |
1.05
|
(0.33-3.33)
|
0.37*
|
(0.17-0.81)
|
0.81
|
(0.58-1.12)
|
|
T1:
|
0.8
|
to
|
6.4
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
6.5
|
to
|
9.4
| |
0.87
|
(0.38-2.01)
|
1.75
|
(0.83-3.69)
|
1.06
|
(0.74-1.53)
|
|
T3:
|
9.5
|
to
|
42.1
| |
0.82
|
(0.23-2.95)
|
1.06
|
(0.38-2.98)
|
0.97
|
(0.62-1.51)
|
|
Alpha-carotene (mcg)
| | | | | | | |
|
T1:
|
7.4
|
to
|
427.1
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
428.6
|
to
|
916.1
| |
0.64
|
(0.29-1.40)
|
1.44
|
(0.81-2.56)
|
0.99
|
(0.76-1.28)
|
|
T3:
|
917.8
|
to
|
17008.2
| |
1.10
|
(0.55-2.22)
|
0.91
|
(0.48-1.72)
|
1.06
|
(0.80-1.40)
|
|
T1:
|
7.4
|
to
|
427.1
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
428.6
|
to
|
916.1
| |
0.65
|
(0.28-1.53)
|
.12*
|
(1.08-4.18)
|
0.88
|
(0.60-1.27)
|
|
T3:
|
917.8
|
to
|
17008.2
| |
1.20
|
(0.57-2.53)
|
1.18
|
(0.57-2.45)
|
1.18
|
(0.81-1.72)
|
|
Beta-carotene (mcg)
| | | | | | | |
|
T1:
|
257.7
|
to
|
2070.1
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
2070.2
|
to
|
3754.1
| |
0.86
|
(0.43-1.74)
|
0.95
|
(0.54-1.68)
|
1.08
|
(0.84-1.39)
|
|
T3:
|
3757.6
|
to
|
39807.1
| |
0.92
|
(0.45-1.90)
|
0.76
|
(0.37-1.54)
|
1.11
|
(0.85-1.46)
|
|
T1:
|
257.7
|
to
|
2070.1
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
2070.2
|
to
|
3754.1
| |
0.79
|
(0.36-1.71)
|
1.36
|
(0.64-2.90)
|
1.06
|
(0.74-1.53)
|
|
T3:
|
3757.6
|
to
|
39807.1
| |
1.08
|
(0.53-2.21)
|
1.45
|
(0.61-3.48)
|
0.97
|
(0.66-1.41)
|
|
Carotenoids (mcg)
| | | | | | | |
|
T1:
|
303.0
|
to
|
2501.5
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
2503.5
|
to
|
4658.0
| |
0.89
|
(0.43-1.84)
|
1.05
|
(0.60-1.82)
|
1.11
|
(0.87-1.43)
|
|
T3:
|
4662.2
|
to
|
51458.1
| |
0.91
|
(0.46-1.82)
|
0.68
|
(0.33-1.41)
|
1.18
|
(0.89-1.55)
|
|
T1:
|
303.0
|
to
|
2501.5
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
2503.5
|
to
|
4658.0
| |
0.74
|
(0.34-1.64)
|
1.70
|
(0.84-3.46)
|
1.13
|
(0.78-1.63)
|
|
T3:
|
4662.2
|
to
|
51458.1
| |
1.02
|
(0.50-2.06)
|
1.21
|
(0.50-2.90)
|
1.02
|
(0.69-1.50)
|
|
Lutein (mcg)
| | | | | | | |
|
T1:
|
31.3
|
to
|
1285.5
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
1288.6
|
to
|
2687.6
| |
0.69
|
(0.36-1.35)
|
0.60
|
(0.35-1.02)
|
0.96
|
(0.74-1.23)
|
|
T3:
|
2694.2
|
to
|
51290.4
| |
0.56
|
(0.26-1.18)
|
1.03
|
(0.53-2.01)
|
1.19
|
(0.92-1.53)
|
|
T1:
|
31.3
|
to
|
1285.5
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
1288.6
|
to
|
2687.6
| |
0.70
|
(0.35-1.43)
|
1.11
|
(0.55-2.26)
|
1.06
|
(0.73-1.53)
|
|
T3:
|
2694.2
|
to
|
51290.4
| |
0.65
|
(0.30-1.41)
|
1.86
|
(0.72-4.78)
|
1.07
|
(0.74-1.53)
|
|
Lycopene (mcg)
| | | | | | | |
|
T1:
|
0.0
|
to
|
914.8
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
915.8
|
to
|
2118.3
| |
1.78
|
(0.92-3.46)
|
1.33
|
(0.77-2.31)
|
1.27
|
(0.99-1.62)
|
|
T3:
|
2121.5
|
to
|
26788.8
| |
0.81
|
(0.37-1.80)
|
0.70
|
(0.36-1.36)
|
1.10
|
(0.85-1.44)
|
|
T1:
|
0.0
|
to
|
914.8
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
915.8
|
to
|
2118.3
| |
2.31*
|
(1.12-4.75)
|
2.17*
|
(1.02-4.62)
|
1.10
|
(0.77-1.57)
|
|
T3:
|
2121.5
|
to
|
26788.8
| |
1.00
|
(0.41-2.44)
|
2.31
|
(0.98-5.43)
|
1.00
|
(0.69-1.44)
|
|
Cryptoxanthin (mcg)
| | | | | | | |
|
T1:
|
0.0
|
to
|
79.8
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
80.2
|
to
|
180.3
| |
1.52
|
(0.70-3.29)
|
0.66
|
(0.37-1.18)
|
1.34*
|
(1.04-1.73)
|
|
T3:
|
180.4
|
to
|
1437.2
| |
0.92
|
(0.39-2.17)
|
1.24
|
(0.66-2.33)
|
1.57*
|
(1.20-2.06)
|
|
T1:
|
0.0
|
to
|
79.8
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
80.2
|
to
|
180.3
| |
1.83
|
(0.86-3.92)
|
1.04
|
(0.51-2.14)
|
1.19
|
(0.82-1.72)
|
|
T3:
|
180.4
|
to
|
1437.2
| |
0.85
|
(0.35-2.08)
|
1.14
|
(0.52-2.51)
|
1.32
|
(0.90-1.93)
|
|
Coumestrol (mcg)
| | | | | | | |
|
T1:
|
3.0
|
to
|
83.4
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
84.1
|
to
|
145.3
| |
0.99
|
(0.51-1.90)
|
0.70
|
(0.38-1.30)
|
1.13
|
(0.88-1.45)
|
|
T3:
|
145.5
|
to
|
1315.3
| |
0.77
|
(0.33-1.75)
|
1.06
|
(0.60-1.87)
|
1.16
|
(0.88-1.54)
|
|
T1:
|
3.0
|
to
|
83.4
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
84.1
|
to
|
145.3
| |
1.11
|
(0.56-2.21)
|
1.41
|
(0.67-2.96)
|
0.98
|
(0.68-1.40)
|
|
T3:
|
145.5
|
to
|
1315.3
| |
0.73
|
(0.29-1.82)
|
0.96
|
(0.45-2.05)
|
1.06
|
(0.72-1.57)
|
|
Matairesinol (mcg)
| | | | | | | |
|
T1:
|
0.1
|
to
|
17.6
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
17.7
|
to
|
34.5
| |
1.17
|
(0.55-2.49)
|
0.88
|
(0.51-1.52)
|
1.38*
|
(1.08-1.77)
|
|
T3:
|
34.6
|
to
|
218.6
| |
0.78
|
(0.36-1.69)
|
0.86
|
(0.48-1.54)
|
1.20
|
(0.92-1.57)
|
|
T1:
|
0.1
|
to
|
17.6
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
17.7
|
to
|
34.5
| |
1.14
|
(0.52-2.50)
|
1.27
|
(0.59-2.73)
|
1.34
|
(0.95-1.89)
|
|
T3:
|
34.6
|
to
|
218.6
| |
0.88
|
(0.38-2.04)
|
1.00
|
(0.48-2.09)
|
1.07
|
(0.74-1.55)
|
|
Secoisolariciresinol (mcg)
| | | | | | | |
|
T1:
|
6.3
|
to
|
87.3
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
87.4
|
to
|
146.0
| |
1.25
|
(0.60-2.61)
|
0.54*
|
(0.31-0.93)
|
1.04
|
(0.81-1.33)
|
|
T3:
|
146.1
|
to
|
698.4
| |
1.95
|
(0.93-4.10)
|
0.48*
|
(0.25-0.92)
|
1.32*
|
(1.02-1.72)
|
|
T1:
|
6.3
|
to
|
87.3
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
87.4
|
to
|
146.0
| |
1.19
|
(0.52-2.73)
|
0.75
|
(0.38-1.49)
|
0.83
|
(0.58-1.21)
|
|
T3:
|
146.1
|
to
|
698.4
| |
1.41
|
(0.63-3.15)
|
0.51
|
(0.22-1.19)
|
0.95
|
(0.66-1.36)
|
|
Linoleic acid (g)
| | | | | | | |
|
T1:
|
1.6
|
to
|
8.9
|
ALL
|
1
| |
1
| |
1
| |
|
T2:
|
9.0
|
to
|
14.6
| |
1.21
|
(0.57-2.58)
|
1.15
|
(0.66-2.02)
|
1.03
|
(0.80-1.32)
|
|
T3:
|
14.7
|
to
|
57.7
| |
0.95
|
(0.35-2.60)
|
0.50
|
(0.25-1.01)
|
0.87
|
(0.63-1.19)
|
|
T1:
|
1.6
|
to
|
8.9
|
SR
|
1
| |
1
| |
1
| |
|
T2:
|
9.0
|
to
|
14.6
| |
1.14
|
(0.51-2.53)
|
0.88
|
(0.41-1.89)
|
0.85
|
(0.60-1.21)
|
|
T3:
|
14.7
|
to
|
57.7
| |
1.17
|
(0.41-3.35)
|
0.59
|
(0.23-1.52)
|
0.96
|
(0.60-1.54)
|
-
† adjusted for reporting status (all cases vs self reported cases only), age at diagnosis (<48,48-65,>65), treatment (radiation, chemo, surgery - yes/no), education (<12, 12, >12), marital status (yes/no), total calories (continuous), pack years (median = 18.5), and age at first alcoholic drink (<18,18-20,>20).
- * p < 0.05
