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Table 1 Effects of GF on the dynamic instability parameters of individual MTs

From: Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine

  GF (μM)
  0 5 15
Rate (μm/min)    
Growing 18.5 ± 4 12.0 ± 2.2 a 10.0 ± 2.0a
Shortening 19.6 ± 5 12.7 ± 4.6 a 10.1 ± 2.6a
Length Change (μm)    
Growth length 2.0 ± 0.8 1.4 ± 0.6b 1.0 ± 0.4a
Shortening length 2.4 ± 0.7 1.4 ± 1c 1.0 ± 0.3a
% Time in phase    
Growing 44.0 ± 10 33.0 ± 10a 20.5 ± 6a
Shortening 25.5 ± 10 14.5 ± 5a 17.5 ± 4b
Pause 30.5 ± 9 52.5 ± 9a 62.0 ± 9a
Frequency (events/min)    
Catastrophe 4.0 ± 2 1.6 ± 0.5a 2.3 ± 0.8b
Rescue 10.0 ± 3 10.0 ± 4d 10.0 ± 2.6c
Frequency (events/μm)    
Catastrophe 0.40 ± 0.2 0.5 ± 0.3d 1.1 ± 0.5a
Rescue 0.6 ± 0.3 0.9 ± 0.5b 1.1 ± 0.3a
Dynamicity (μm/min) 13.7 ± 4 5.7 ± 2a 3.8 ± 1.2a
  1. Data are average ± SD, n = 22 MTs in control and n = 21 MTs in 5 & 15 mM GF treated cells; a, P < 0.001; b, P < 0.01; c, P < 0.05; d, statistically not significant