Figure 2
From: The siRNA targeted to mdr1b and mdr1a mRNAs in vivosensitizes murine lymphosarcoma to chemotherapy
The levels of Pgp activity in the RLS 40 cells treated with siRNA according to Rh123 efflux assay. (A) Flow cytometry data showing the inhibitory effect of Verapamil and specific mdr1b/1a siRNA (200 nM, 48 h after transfection). (B) Dose and time dependences of the Rh123 accumulation in RLS40 cells mediated by mdr1b and mdr1a gene silencing induced by mdr1b/1a siRNA. The plots show the data of three independent experiments.