Table 1 IC50 values for GF109203X, GÖ6976, RO31-8220 (each nM) and Rottlerin (μM) for inhibition of PKC isoforms (from: Goekjian and Jirousek, 1999 [35] and Gschwendt et al., 1994 [62])
From: Adhesion of renal carcinoma cells to endothelial cells depends on PKCμ
Inhibitors | PKC isoforms | ||||||||
|---|---|---|---|---|---|---|---|---|---|
α | βI | βII | γ | δ | ε | η | ξ | μ | |
GF109203X [nM] | 14 | 18 | 16 | 20 | 210 | 132 | 5800 | 2000 | |
GÖ6976 [nM] | 2.3 | 6.2 | >10000 | >10000 | 685 | >10000 | 20 | ||
RO31-8220 [nM] | 5 | 24 | 14 | 27 | 24 | ||||
Rottlerin [μM] | 30 | 42 | 40 | 3-6 | 100 | 82 | 100 | ||