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Table 2 Genotype frequencies of MLH1 -93G>A polymorphism in sporadic MSI-H colon cancer with an age of onset below and above 50 years.

From: Early onset MSI-H colon cancer with MLH1 promoter methylation, is there a genetic predisposition?

  

Genotype frequency (%)

   
 

n

GG

GA

AA

Chi-square

DF

P-value

Age at diagnosis <50

13

4(31)

7(54)

2(15)

   

Controls 1

929

554(59.5)

331(35.5)

44(5)

6.0

2

0.19427123*

Controls 2<60

501

287(57)

175(35)

39(8)

3.8

2

0.34061584*

Age of diagnosis ≥ 50

28

8(29)

14(50)

6(21)

   

Controls 1

929

554(59.5)

331(35.5)

44(5)

20.5

2

0.00003502

Controls 2>60

1462

883(60)

513(35)

66(5)

22.6

2

0.00001209

  

GG

GA+AA

 

Chi-square

DF

P-value

Age at diagnosis <50

13

4(31)

9(69)

    

Controls 1

929

554(60)

375(40)

 

4.4

1

0.06890141*

Controls 2<60

501

287(57)

214(43)

 

3.6

1

0.10499389*

Age at diagnosis ≥ 50

28

8(29)

20(71)

    

Controls 1

929

554(60)

375(40)

 

10.8

1

0.00100409

Controls 2 >60

1462

883(60)

579(40)

 

11.6

1

0.00066844

  1. n: Total number
  2. Chi-square: Value of the chi-square test
  3. DF: Degrees of freedom
  4. Control samples are adapted from literature. Percentages are given in brackets. (Raptis et al., for controls 1 and Samowitz et al. for controls 2 [22, 24]). P-values with a * are Yates corrected.
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BMC Cancer

ISSN: 1471-2407

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