Skip to main content

Table 1 Pulmonary tumor cell adhesion in vivo

From: In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell - endothelial cell interaction

Treatment Time intervall after cell injection [min]
  0-10 11-20 21-30 31-40
  adherent cells/20 microscopic fileds [mean ± SD]
T 84
control IgG [n = 6]
16.7 ± 9.0 15.8 ± 5.1 14.1 ± 5.6 13.0 ± 1.9
HT-29 LMM
control IgG [n = 9]
13.5 ± 5.1 13.5 ± 4.8 11.1 ± 2.7 13.5 ± 2.3
anti integrin-β1 [n = 7] 11.4 ± 4.7 11.8 ± 4.4 12.9 ± 2.7 12.3 ± 3.8
anti integrin-β4 [n = 10] 13.4 ± 7.6 10.7 ± 4.0 10.4 ± 3.2 11.0 ± 4.5
anti integrin-αv [n = 8] 10.6 ± 5.1 10.1 ± 4.1 9.5 ± 2.5 11.7 ± 2.7
vehicle [n = 12] 12.8 ± 4.7 13.2 ± 6.7 10.9 ± 3.9 15.0 ± 5.9
neuraminidase type V [n = 8] 7.4 ± 3.0 6.6 ± 2.3* 6.5 ± 2.6* 7.9 ± 2.9**
fucoidane (animals) [n = 7] 11.6 ± 6.9 7.4 ± 3.1* 7.2 ± 3.3* 5.6 ± 2.5**
control medium [n = 5] 10.9 ± 5.1 18.3 ± 10.1 16.4 ± 3.9 14.8 ± 6.1
anti galectin-3 [n = 5] 18.8 ± 6.7 13.3 ± 2.4 13.1 ± 2.9 12.3 ± 3.2
anti TF [n = 4] 11.5 ± 14.7 7.9 ± 4.7* 8.6 ± 3.7** 7.2 ± 4.0*
anti TF + anti galectin-3 [n = 5] 11.6 ± 1.0 7.4 ± 2.8** 7.3 ± 2.3** 6.5 ± 1.4**
  1. ANOVA and post hoc (LSD):
  2. * p < 0.05
  3. ** p < 0.001