Figure 6

Apoptosis and cell cycle parameters for sub-populations of NOK. Apoptotic rates and cell cycle parameters for CD44^high and CD44^low cell fractions of early passage normal oral keratinocytes. CD44^high cells (right panel of each pair) show lower rates of apoptosis and a higher proportion of cells in G2 (both p < 0.05) than the CD44^low sub-population (left panel of each pair) (A, B). Treatment with UVB and Cisplatin increases apoptosis (C, E), but the proportion of CD44^high cells in apoptosis remains markedly lower (p < 0.01). UVB and NCZ treatment is also associated with increases in the proportion of CD44^high cells in G2 and decrease in G1 phase of the cell cycle (D, F).