Table 3 Enzyme activity of the complexes of the OXPHOS system.
From: Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma
| Â | Kidney (n = 15)* | Tumor (n = 14)* | P value |
|---|---|---|---|
Citrate synthase [mUnits/mg protein] | 110 ± 7 | 119 ± 8 | 0.4088 |
Complex I [mUnits/mg protein] | 43 ± 2 | 10 ± 2 | <0.0001 |
Complex I/citrate synthase | 0.40 ± 0.02 | 0.09 ± 0.02 | <0.0001 |
Complex II [mUnits/mg protein] | 128 ± 11 | 15 ± 4 | <0.0001 |
Complex II/citrate synthase | 1.13 ± 0.06 | 0.14 ± 0.04 | <0.0001 |
Complex III [mUnits/mg protein] | 159 ± 9 | 101 ± 9 | <0.0001 |
Complex III/citrate synthase | 1.50 ± 0.09 | 0.92 ± 0.11 | 0.0002 |
Complex IV [mUnits/mg protein] | 100 ± 8 | 28 ± 3 | <0.0001 |
Complex IV/citrate synthase | 0.90 ± 0.05 | 0.25 ± 0.03 | <0.0001 |
ATP synthase [mUnits/mg protein] | 41 ± 4 | 9 ± 2 | <0.0001 |
ATP synthase/citrate synthase | 0.38 ± 0.04 | 0.08 ± 0.02 | <0.0001 |
mtDNA copy number | 2960 ± 431 | 194 ± 22 | <0.0001 |