|
Variable
|
n
|
HRa
|
95% CI
|
p-valueb
|
|---|
|
Tumor thickness
| | | |
ns
|
|
≤2.0 mm
|
43
|
1
| | |
|
2.1-4.0 mm
|
64
|
1.3
|
0.5 to 3.2
|
ns
|
|
>4.0 mm
|
72
|
1.1
|
0.4 to 2.9
|
ns
|
|
Tumor ulceration
| | | |
ns
|
|
absent
|
101
|
1
| | |
|
present
|
78
|
1.3
|
0.7 to 2.3
| |
|
Clark's level
| | | |
0.009
|
|
II - IV
|
146
|
1
| | |
|
V
|
33
|
2.5
|
1.3 to 4.9
| |
|
Vascular infiltration
| | | |
0.008
|
|
absent
|
143
|
1
| | |
|
present
|
36
|
2.3
|
1.3 to 4.0
| |
|
Tumor necrosis
| | | |
0.015
|
|
absent
|
127
|
1
| | |
|
present
|
52
|
2.1
|
1.2 to 3.8
| |
|
Mitotic count (no./mm2)
| | | |
ns
|
|
<1.7c
|
34
|
1
| | |
|
≥1.7
|
145
|
1.5
|
0.5 to 3.9
| |
|
Ki-67 (% pos)
| | | |
0.006
|
|
≤16c
|
48
|
1
| | |
|
>16
|
131
|
3.0
|
1.3 to 7.3
| |
-
aHazard ratio
-
bLikelihood ratio or Wald test
-
cCut-off point lower quartile
