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Table 5 Multivariate survival analysis (Cox' proportional hazards method)
| Variable | n | HRa | 95% CI | p-valueb | |
|---|---|---|---|---|---|
| Tumor thickness | ns | ||||
| ≤2.0 mm | 43 | 1 | |||
| 2.1-4.0 mm | 64 | 1.3 | 0.5 to 3.2 | ns | |
| >4.0 mm | 72 | 1.1 | 0.4 to 2.9 | ns | |
| Tumor ulceration | ns | ||||
| absent | 101 | 1 | |||
| present | 78 | 1.3 | 0.7 to 2.3 | ||
| Clark's level | 0.009 | ||||
| II - IV | 146 | 1 | |||
| V | 33 | 2.5 | 1.3 to 4.9 | ||
| Vascular infiltration | 0.008 | ||||
| absent | 143 | 1 | |||
| present | 36 | 2.3 | 1.3 to 4.0 | ||
| Tumor necrosis | 0.015 | ||||
| absent | 127 | 1 | |||
| present | 52 | 2.1 | 1.2 to 3.8 | ||
| Mitotic count (no./mm2) | ns | ||||
| <1.7c | 34 | 1 | |||
| ≥1.7 | 145 | 1.5 | 0.5 to 3.9 | ||
| Ki-67 (% pos) | 0.006 | ||||
| ≤16c | 48 | 1 | |||
| >16 | 131 | 3.0 | 1.3 to 7.3 | ||
