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Table 5 Multivariate survival analysis (Cox' proportional hazards method)

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

Variable n HRa 95% CI p-valueb
Tumor thickness     ns
   ≤2.0 mm 43 1   
   2.1-4.0 mm 64 1.3 0.5 to 3.2 ns
   >4.0 mm 72 1.1 0.4 to 2.9 ns
Tumor ulceration     ns
   absent 101 1   
   present 78 1.3 0.7 to 2.3  
Clark's level     0.009
   II - IV 146 1   
   V 33 2.5 1.3 to 4.9  
Vascular infiltration     0.008
   absent 143 1   
   present 36 2.3 1.3 to 4.0  
Tumor necrosis     0.015
   absent 127 1   
   present 52 2.1 1.2 to 3.8  
Mitotic count (no./mm2)     ns
   <1.7c 34 1   
   ≥1.7 145 1.5 0.5 to 3.9  
Ki-67 (% pos)     0.006
   ≤16c 48 1   
   >16 131 3.0 1.3 to 7.3  
  1. aHazard ratio
  2. bLikelihood ratio or Wald test
  3. cCut-off point lower quartile