Table 5 Multivariate survival analysis (Cox' proportional hazards method)
Variable | n | HRa | 95% CI | p-valueb | |
|---|---|---|---|---|---|
Tumor thickness | ns | ||||
≤2.0 mm | 43 | 1 | |||
2.1-4.0 mm | 64 | 1.3 | 0.5 to 3.2 | ns | |
>4.0 mm | 72 | 1.1 | 0.4 to 2.9 | ns | |
Tumor ulceration | ns | ||||
absent | 101 | 1 | |||
present | 78 | 1.3 | 0.7 to 2.3 | ||
Clark's level | 0.009 | ||||
II - IV | 146 | 1 | |||
V | 33 | 2.5 | 1.3 to 4.9 | ||
Vascular infiltration | 0.008 | ||||
absent | 143 | 1 | |||
present | 36 | 2.3 | 1.3 to 4.0 | ||
Tumor necrosis | 0.015 | ||||
absent | 127 | 1 | |||
present | 52 | 2.1 | 1.2 to 3.8 | ||
Mitotic count (no./mm2) | ns | ||||
<1.7c | 34 | 1 | |||
≥1.7 | 145 | 1.5 | 0.5 to 3.9 | ||
Ki-67 (% pos) | 0.006 | ||||
≤16c | 48 | 1 | |||
>16 | 131 | 3.0 | 1.3 to 7.3 | ||