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Table 4 Multivariate survival analysis (Cox' proportional hazards method)

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

Variable n HRa 95% CI p-valueb
Tumor thickness     0.073
   ≤2.0 mm 43 1   
   2.1-4.0 mm 65 1.7 0.7 to 4.1 ns
   >4.0 mm 72 2.5 1.04 to 5.8 0.041
Tumor ulceration     0.083
   absent 102 1   
   present 78 1.6 0.9 to 2.6  
Mitotic count (no./mm2)     ns
   <1.7c 34 1   
   ≥1.7 146 1.5 0.6 to 3.9  
Ki-67 (% pos)     0.003
   ≤16c 48 1   
   >16 132 3.1 1.3 to 7.4  
  1. aHazard ratio
  2. bLikelihood ratio or Wald test
  3. cCut-off point lower quartile