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Table 4 Multivariate survival analysis (Cox' proportional hazards method)

From: Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma

Variable

n

HRa

95% CI

p-valueb

Tumor thickness

   

0.073

   ≤2.0 mm

43

1

  

   2.1-4.0 mm

65

1.7

0.7 to 4.1

ns

   >4.0 mm

72

2.5

1.04 to 5.8

0.041

Tumor ulceration

   

0.083

   absent

102

1

  

   present

78

1.6

0.9 to 2.6

 

Mitotic count (no./mm2)

   

ns

   <1.7c

34

1

  

   ≥1.7

146

1.5

0.6 to 3.9

 

Ki-67 (% pos)

   

0.003

   ≤16c

48

1

  

   >16

132

3.1

1.3 to 7.4

 
  1. aHazard ratio
  2. bLikelihood ratio or Wald test
  3. cCut-off point lower quartile