Category | Serum OPN protein level in ng/ml | Tumor OPN protein level in ng/mg | Tumor OPN mRNA level in molecules/pg HPRT | |||
---|---|---|---|---|---|---|
≤ 516.54 | >516.54 | ≤ 34.34 | >34.34 | ≤ 0.576 | >0.576 | |
Total | 21 | 65 | 20 | 60 | 17 | 51 |
Tumor stage | p = 0.004* | p = 0.06 | p = 0.21 | |||
I | 8 | 6 | 7 | 6 | 5 | 7 |
II | 10 | 27 | 7 | 25 | 7 | 19 |
III | 2 | 24 | 4 | 22 | 5 | 17 |
IV | 1 | 8 | 2 | 7 | 0 | 8 |
Tumor type | p = 0.002* | p = 0.07 | p = 0.19 | |||
LS | 12 | 9 | 10 | 11 | 5 | 13 |
FS+MFH | 4 | 20 | 3 | 17 | 6 | 11 |
NS | 0 | 8 | 2 | 5 | 2 | 1 |
RMS+LMS | 3 | 19 | 4 | 18 | 3 | 17 |
Other STS | 2 | 9 | 1 | 9 | 1 | 9 |
Tumor size | p = 0.03* | p = 0.85 | p = 0.24 | |||
T1 | 6 | 6 | 3 | 8 | 1 | 9 |
T2 | 15 | 59 | 17 | 52 | 16 | 42 |
Distant metastasis | p = 0.12 | p = 0.82 | p = 0.14 | |||
M0 | 21 | 58 | 18 | 55 | 17 | 45 |
M1 | 0 | 7 | 2 | 5 | 0 | 6 |
Relapse | p = 0.41 | p = 0.02* | p = 0.88 | |||
R0 | 15 | 40 | 17 | 34 | 12 | 35 |
R1 | 6 | 25 | 3 | 26 | 5 | 16 |
Follow-up | ||||||
Alive | 14 | 29 | 16 | 21 | 11 | 23 |
Dead | 7 | 36 | 4 | 39 | 6 | 28 |
Kaplan-Meier analysis | p = 0.04* | p = 0.007* | p = 0.2 | |||
mean survival in months | 103 | 60 | 68 | 58 | 72 | 65 |
Cox's-Regression model | p < 0.05* | p = 0.01* | p = 0.21 | |||
RR | 2.2 | 3.7 | 1.7 | |||
CI | 1.0-5.1 | 1.3-10.4 | 0.7-4.3 |