Figure 2

Lovastatin-induced apoptosis of ovarian cancer cells occurs at therapeutically achievable levels. A2780 cells were exposed to a range of lovastatin concentrations or vehicle control for 24, 48, or 72 hours to demonstrate the dose- and time- dependence of lovastatin-induced apoptosis as measured by fixed PI analysis. Results are normalized to each vehicle control (= 1%) and are presented as the mean of 3 independent experiments with error bars representing standard deviation. Dashed line highlights equivalence between doses of 20 μM for 24 hours and 5 μM for 72 hours. *, p < 0.05 compared to the untreated controls by a Student's t-Test.