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  1. Study protocol

    CMISG1701: a multicenter prospective randomized phase III clinical trial comparing neoadjuvant chemoradiotherapy to neoadjuvant chemotherapy followed by minimally invasive esophagectomy in patients with locally advanced resectable esophageal squamous cell carcinoma (cT3-4aN0-1M0) (NCT03001596)

    Neoadjuvant chemoradiation is not recommended as an approach for treatment of esophageal squamous cell carcinoma due to its significant postoperative mortality. However, it is assumed the combination of neoadj...

    Han Tang, Lijie Tan, Yaxing Shen, Hao Wang, Miao Lin, Mingxiang Feng, Songtao Xu, Weigang Guo, Cheng Qian, Tianshu Liu, Zhaochong Zeng, Yingyong Hou, Zhentao Yu, Hongjing Jiang, Zhigang Li, Chun Chen…

    BMC Cancer 2017 17:450

    Published on: 28 June 2017

  2. Study protocol

    The effect of geriatric intervention in frail elderly patients receiving chemotherapy for colorectal cancer: a randomized trial (GERICO)

    Better surgical techniques, chemotherapy and biological therapy have improved survival in patients with colorectal cancer (CRC), most markedly in younger patients. About half of patients over 70 years receive ...

    C. M. Lund, K. K. Vistisen, C. Dehlendorff, F. Rønholt, J. S. Johansen and D. L. Nielsen

    BMC Cancer 2017 17:448

    Published on: 28 June 2017

  3. Research article

    Prognostic and predictive factors in patients with metastatic or recurrent cervical cancer treated with platinum-based chemotherapy.

    Recognizing resistance or susceptibility to the current standard cisplatin and paclitaxel treatment could improve therapeutic outcomes of metastatic or recurrent cervical cancer.

    Sofia Karageorgopoulou, Ioannis D. Kostakis, Maria Gazouli, Sonia Markaki, Marios Papadimitriou, Evangelos Bournakis, Meletios-Athanassios Dimopoulos and Christos A Papadimitriou

    BMC Cancer 2017 17:451

    Published on: 28 June 2017

  4. Research article

    Targeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis

    Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and is an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin is the most commonly ...

    Xinfang Yu, Wei Li, Zhenkun Xia, Li Xie, Xiaolong Ma, Qi Liang, Lijun Liu, Jian Wang, Xinmin Zhou, Yifeng Yang and Haidan Liu

    BMC Cancer 2017 17:449

    Published on: 28 June 2017

  5. Research article

    Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration

    Epithelial to mesenchymal transition (EMT) is the process by which stationary epithelial cells transdifferentiate to mesenchymal cells with increased motility. EMT is integral in early stages of development an...

    Princy Parsana, Sarah R. Amend, James Hernandez, Kenneth J. Pienta and Alexis Battle

    BMC Cancer 2017 17:447

    Published on: 26 June 2017

  6. Research article

    Clinical outcomes of transoral videolaryngoscopic surgery for hypopharyngeal and supraglottic cancer

    Transoral videolaryngoscopic surgery (TOVS) was developed as a new distinct surgical procedure for hypopharyngeal cancer (HPC) and supraglottic cancer (SGC) staged at up to T3. However, long-term treatment out...

    Yorihisa Imanishi, Hiroyuki Ozawa, Koji Sakamoto, Ryoichi Fujii, Seiji Shigetomi, Noboru Habu, Kuninori Otsuka, Yoichiro Sato, Yoshihiro Watanabe, Mariko Sekimizu, Fumihiro Ito, Toshiki Tomita and Kaoru Ogawa

    BMC Cancer 2017 17:445

    Published on: 26 June 2017

  7. Study protocol

    Development of a computer-tailored physical activity intervention for prostate and colorectal cancer patients and survivors: OncoActive

    Cancer and cancer treatment coincide with substantial negative physical, psychological and psychosocial problems. Physical activity (PA) can positively affect the negative effects of cancer and cancer treatmen...

    R. H. J. Golsteijn, C. Bolman, E. Volders, D. A. Peels, H. de Vries and L. Lechner

    BMC Cancer 2017 17:446

    Published on: 26 June 2017

  8. Study protocol

    Within-class differences in cancer risk for sulfonylurea treatments in patients with type 2 diabetes (ZODIAC-55) – a study protocol

    Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world’s population is living with T2D, even a slight increase in cancer risk could result in an enorm...

    Dennis Schrijnders, Geertruida H. de Bock, Sebastiaan T. Houweling, Kornelis J. J. van Hateren, Klaas H. Groenier, Jeffrey A. Johnson, Henk J. G. Bilo, Nanne Kleefstra and Gijs W. D. Landman

    BMC Cancer 2017 17:444

    Published on: 23 June 2017

  9. Research article

    Acute myeloid leukemia and pregnancy: clinical experience from a single center and a review of the literature

    Acute myeloid leukemia (AML) accounts for more than two thirds of leukemia during pregnancy and has an incidence of 1 in 75,000 to 100,000. Its clinical management remains a challenging therapeutic task both f...

    Nicola Stefano Fracchiolla, Mariarita Sciumè, Francesco Dambrosi, Francesca Guidotti, Manuela Wally Ossola, Giovanna Chidini, Umberto Gianelli, Daniela Merlo and Agostino Cortelezzi

    BMC Cancer 2017 17:442

    Published on: 23 June 2017

  10. Research article

    A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model

    As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Bo...

    Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi and Chia-Hwa Lee

    BMC Cancer 2017 17:440

    Published on: 23 June 2017

  11. Research article

    The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

    The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis. In this study, we aimed to assess the role of the Hip...

    KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh and Ja-June Jang

    BMC Cancer 2017 17:441

    Published on: 23 June 2017

  12. Study protocol

    Cerebellar mutism syndrome in children with brain tumours of the posterior fossa

    Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of poste...

    Morten Wibroe, Johan Cappelen, Charlotte Castor, Niels Clausen, Pernilla Grillner, Thora Gudrunardottir, Ramneek Gupta, Bengt Gustavsson, Mats Heyman, Stefan Holm, Atte Karppinen, Camilla Klausen, Tuula Lönnqvist, René Mathiasen, Pelle Nilsson, Karsten Nysom…

    BMC Cancer 2017 17:439

    Published on: 21 June 2017

  13. Research article

    Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

    Identification of BRCA mutations in breast cancer (BC) patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria. ...

    Eli Marie Grindedal, Cecilie Heramb, Inga Karsrud, Sarah Louise Ariansen, Lovise Mæhle, Dag Erik Undlien, Jan Norum and Ellen Schlichting

    BMC Cancer 2017 17:438

    Published on: 21 June 2017

  14. Case report

    Curative resection by splenectomy for solitary splenic metastasis from early gastric cancer: a case report and literature review

    Solitary metastasis of a malignancy to the spleen is rare, particularly for gastric cancer. Only a few case reports have documented isolated splenic metastasis from early gastric cancer. We describe a case of ...

    Junichi Yoshizawa, Naoki Kubo, Satoshi Ishizone, Fumitoshi Karasawa and Ataru Nakayama

    BMC Cancer 2017 17:436

    Published on: 20 June 2017

  15. Research article

    Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

    To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC).

    Dan Liu, Jian Li, Jing Gao, Yanyan Li, Rui Yang and Lin Shen

    BMC Cancer 2017 17:437

    Published on: 20 June 2017

  16. Research article

    Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

    Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through rou...

    Anderson H. Webb, Bradley T. Gao, Zachary K. Goldsmith, Andrew S. Irvine, Nabil Saleh, Ryan P. Lee, Justin B. Lendermon, Rajini Bheemreddy, Qiuhua Zhang, Rachel C. Brennan, Dianna Johnson, Jena J. Steinle, Matthew W. Wilson and Vanessa M. Morales-Tirado

    BMC Cancer 2017 17:434

    Published on: 20 June 2017

  17. Research article

    HPV and cofactors for invasive cervical cancer in Morocco: a multicentre case-control study

    Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub...

    Mohamed Berraho, Afaf Amarti-Riffi, Mohammed El-Mzibri, Rachid Bezad, Noureddine Benjaafar, Abdelatif Benideer, Noureddine Matar, Zinab Qmichou, Naima Abda, Mohammed Attaleb, Kaoutar Znati, Hind El Fatemi, Karima Bendahhou, Majdouline Obtel, Abdelhai Filali Adib, Simone Mathoulin-Pelissier…

    BMC Cancer 2017 17:435

    Published on: 20 June 2017

  18. Study protocol

    Personalised informed choice on evidence and controversy on mammography screening: study protocol for a randomized controlled trial

    In Italy women aged 50–69 are invited for a population-based breast cancer (BC) screening. Physicians, policy makers and patients associations agree on the need to inform women about the benefits and harms in ...

    Anna Roberto, Cinzia Colombo, Giulia Candiani, Livia Giordano, Paola Mantellini, Eugenio Paci, Roberto Satolli, Mario Valenza and Paola Mosconi

    BMC Cancer 2017 17:429

    Published on: 19 June 2017

  19. Research article

    Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis

    P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to ...

    Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J. Dumesny, Mauro S. Sandrin, Graham S. Baldwin, Mehrdad Nikfarjam and Hong He

    BMC Cancer 2017 17:431

    Published on: 19 June 2017

  20. Research article

    Strain elastography imaging for early detection and prediction of tumor response to concurrent chemo-radiotherapy in locally advanced cervical cancer: feasibility study

    To investigate the feasibility of strain elastography imaging in early detecting and predicting treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for locally advanced cervical cancer.

    Yan Xu, Lijing Zhu, Baorui Liu, Tong Ru, Huanhuan Wang, Jian He, Song Liu, Xiaofeng Yang, Zhengyang Zhou and Tian Liu

    BMC Cancer 2017 17:427

    Published on: 19 June 2017

  21. Research article

    Droplet digital PCR for detection and quantification of circulating tumor DNA in plasma of head and neck cancer patients

    During posttreatment surveillance of head and neck cancer patients, imaging is insufficiently accurate for the early detection of relapsing disease. Free circulating tumor DNA (ctDNA) may serve as a novel biom...

    Joost H. van Ginkel, Manon M. H. Huibers, Robert J. J. van Es, Remco de Bree and Stefan M. Willems

    BMC Cancer 2017 17:428

    Published on: 19 June 2017

  22. Research article

    Utility of the sentinel node concept for detection of lateral pelvic lymph node metastasis in lower rectal cancer

    There are two lymphatic flows in lower rectal cancer; one along the inferior mesenteric artery and another towards the internal iliac artery. The benefit of dissection of lateral pelvic (LP) lymph nodes (LPLN)...

    Shigehiro Yanagita, Yoshikazu Uenosono, Takaaki Arigami, Yoshiaki Kita, Shinichiro Mori and Shoji Natsugoe

    BMC Cancer 2017 17:433

    Published on: 19 June 2017

  23. Research article

    Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder

    The protein kinase C (PKC) family comprises central regulators of multiple signal transduction processes and is involved in the progression of many cancers. Nuclear factor Kappa-B (NF-κB) is constitutively exp...

    Jin Zheng, Chuize Kong, Xiaoxi Yang, Xiaolu Cui, Xuyong Lin and Zhe Zhang

    BMC Cancer 2017 17:432

    Published on: 19 June 2017

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