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  1. Research article

    Acute myeloid leukemia and pregnancy: clinical experience from a single center and a review of the literature

    Acute myeloid leukemia (AML) accounts for more than two thirds of leukemia during pregnancy and has an incidence of 1 in 75,000 to 100,000. Its clinical management remains a challenging therapeutic task both f...

    Nicola Stefano Fracchiolla, Mariarita Sciumè, Francesco Dambrosi, Francesca Guidotti, Manuela Wally Ossola, Giovanna Chidini, Umberto Gianelli, Daniela Merlo and Agostino Cortelezzi

    BMC Cancer 2017 17:442

    Published on: 23 June 2017

  2. Research article

    A rapid and quantitative method to detect human circulating tumor cells in a preclinical animal model

    As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Bo...

    Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi and Chia-Hwa Lee

    BMC Cancer 2017 17:440

    Published on: 23 June 2017

  3. Research article

    The correlation between poor prognosis and increased yes-associated protein 1 expression in keratin 19 expressing hepatocellular carcinomas and cholangiocarcinomas

    The Hippo pathway plays a vital role in liver regeneration and development by determining cellular lineage and regulating cell proliferation and apoptosis. In this study, we aimed to assess the role of the Hip...

    KyuHo Lee, Kyoung-Bun Lee, Hae Yoen Jung, Nam-Joon Yi, Kwang-Woong Lee, Kyung-Suk Suh and Ja-June Jang

    BMC Cancer 2017 17:441

    Published on: 23 June 2017

  4. Study protocol

    Cerebellar mutism syndrome in children with brain tumours of the posterior fossa

    Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of poste...

    Morten Wibroe, Johan Cappelen, Charlotte Castor, Niels Clausen, Pernilla Grillner, Thora Gudrunardottir, Ramneek Gupta, Bengt Gustavsson, Mats Heyman, Stefan Holm, Atte Karppinen, Camilla Klausen, Tuula Lönnqvist, René Mathiasen, Pelle Nilsson, Karsten Nysom…

    BMC Cancer 2017 17:439

    Published on: 21 June 2017

  5. Research article

    Current guidelines for BRCA testing of breast cancer patients are insufficient to detect all mutation carriers

    Identification of BRCA mutations in breast cancer (BC) patients influences treatment and survival and may be of importance for their relatives. Testing is often restricted to women fulfilling high-risk criteria. ...

    Eli Marie Grindedal, Cecilie Heramb, Inga Karsrud, Sarah Louise Ariansen, Lovise Mæhle, Dag Erik Undlien, Jan Norum and Ellen Schlichting

    BMC Cancer 2017 17:438

    Published on: 21 June 2017

  6. Case report

    Curative resection by splenectomy for solitary splenic metastasis from early gastric cancer: a case report and literature review

    Solitary metastasis of a malignancy to the spleen is rare, particularly for gastric cancer. Only a few case reports have documented isolated splenic metastasis from early gastric cancer. We describe a case of ...

    Junichi Yoshizawa, Naoki Kubo, Satoshi Ishizone, Fumitoshi Karasawa and Ataru Nakayama

    BMC Cancer 2017 17:436

    Published on: 20 June 2017

  7. Research article

    Examination of multiple UGT1A and DPYD polymorphisms has limited ability to predict the toxicity and efficacy of metastatic colorectal cancer treated with irinotecan-based chemotherapy: a retrospective analysis

    To evaluate a new UGT1A and DPYD polymorphism panel to better predict irinotecan-induced toxicity and the clinical response in Chinese patients with metastatic colorectal cancer (mCRC).

    Dan Liu, Jian Li, Jing Gao, Yanyan Li, Rui Yang and Lin Shen

    BMC Cancer 2017 17:437

    Published on: 20 June 2017

  8. Research article

    Inhibition of MMP-2 and MMP-9 decreases cellular migration, and angiogenesis in in vitro models of retinoblastoma

    Retinoblastoma (Rb) is the most common primary intraocular tumor in children. Local treatment of the intraocular disease is usually effective if diagnosed early; however advanced Rb can metastasize through rou...

    Anderson H. Webb, Bradley T. Gao, Zachary K. Goldsmith, Andrew S. Irvine, Nabil Saleh, Ryan P. Lee, Justin B. Lendermon, Rajini Bheemreddy, Qiuhua Zhang, Rachel C. Brennan, Dianna Johnson, Jena J. Steinle, Matthew W. Wilson and Vanessa M. Morales-Tirado

    BMC Cancer 2017 17:434

    Published on: 20 June 2017

  9. Research article

    HPV and cofactors for invasive cervical cancer in Morocco: a multicentre case-control study

    Limited national information is available in Morocco on the prevalence and distribution of HPV-sub-types of cervical cancer and the role of other risk factors. The aim was to determine the frequency of HPV-sub...

    Mohamed Berraho, Afaf Amarti-Riffi, Mohammed El-Mzibri, Rachid Bezad, Noureddine Benjaafar, Abdelatif Benideer, Noureddine Matar, Zinab Qmichou, Naima Abda, Mohammed Attaleb, Kaoutar Znati, Hind El Fatemi, Karima Bendahhou, Majdouline Obtel, Abdelhai Filali Adib, Simone Mathoulin-Pelissier…

    BMC Cancer 2017 17:435

    Published on: 20 June 2017

  10. Study protocol

    Personalised informed choice on evidence and controversy on mammography screening: study protocol for a randomized controlled trial

    In Italy women aged 50–69 are invited for a population-based breast cancer (BC) screening. Physicians, policy makers and patients associations agree on the need to inform women about the benefits and harms in ...

    Anna Roberto, Cinzia Colombo, Giulia Candiani, Livia Giordano, Paola Mantellini, Eugenio Paci, Roberto Satolli, Mario Valenza and Paola Mosconi

    BMC Cancer 2017 17:429

    Published on: 19 June 2017

  11. Research article

    Depletion of p21-activated kinase 1 up-regulates the immune system of APC∆14/+ mice and inhibits intestinal tumorigenesis

    P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to ...

    Nhi Huynh, Kai Wang, Mildred Yim, Chelsea J. Dumesny, Mauro S. Sandrin, Graham S. Baldwin, Mehrdad Nikfarjam and Hong He

    BMC Cancer 2017 17:431

    Published on: 19 June 2017

  12. Research article

    Strain elastography imaging for early detection and prediction of tumor response to concurrent chemo-radiotherapy in locally advanced cervical cancer: feasibility study

    To investigate the feasibility of strain elastography imaging in early detecting and predicting treatment response in patients receiving concurrent chemo-radiotherapy (CCRT) for locally advanced cervical cancer.

    Yan Xu, Lijing Zhu, Baorui Liu, Tong Ru, Huanhuan Wang, Jian He, Song Liu, Xiaofeng Yang, Zhengyang Zhou and Tian Liu

    BMC Cancer 2017 17:427

    Published on: 19 June 2017

  13. Research article

    Droplet digital PCR for detection and quantification of circulating tumor DNA in plasma of head and neck cancer patients

    During posttreatment surveillance of head and neck cancer patients, imaging is insufficiently accurate for the early detection of relapsing disease. Free circulating tumor DNA (ctDNA) may serve as a novel biom...

    Joost H. van Ginkel, Manon M. H. Huibers, Robert J. J. van Es, Remco de Bree and Stefan M. Willems

    BMC Cancer 2017 17:428

    Published on: 19 June 2017

  14. Research article

    Utility of the sentinel node concept for detection of lateral pelvic lymph node metastasis in lower rectal cancer

    There are two lymphatic flows in lower rectal cancer; one along the inferior mesenteric artery and another towards the internal iliac artery. The benefit of dissection of lateral pelvic (LP) lymph nodes (LPLN)...

    Shigehiro Yanagita, Yoshikazu Uenosono, Takaaki Arigami, Yoshiaki Kita, Shinichiro Mori and Shoji Natsugoe

    BMC Cancer 2017 17:433

    Published on: 19 June 2017

  15. Research article

    Protein kinase C-α (PKCα) modulates cell apoptosis by stimulating nuclear translocation of NF-kappa-B p65 in urothelial cell carcinoma of the bladder

    The protein kinase C (PKC) family comprises central regulators of multiple signal transduction processes and is involved in the progression of many cancers. Nuclear factor Kappa-B (NF-κB) is constitutively exp...

    Jin Zheng, Chuize Kong, Xiaoxi Yang, Xiaolu Cui, Xuyong Lin and Zhe Zhang

    BMC Cancer 2017 17:432

    Published on: 19 June 2017

  16. Study protocol

    A phase 2 randomized trial to evaluate the impact of a supervised exercise program on cardiotoxicity at 3 months in patients with HER2 overexpressing breast cancer undergoing adjuvant treatment by trastuzumab: design of the CARDAPAC study

    The overexpression of human epidermal growth factor receptor-2 (HER2) in breast cancer is a poor prognosis. Trastuzumab improves overall survival but is associated with cardiotoxicity, especially a decline in ...

    Quentin Jacquinot, Nathalie Meneveau, Marion Chatot, Franck Bonnetain, Bruno Degano, Malika Bouhaddi, Gilles Dumoulin, Dewi Vernerey, Xavier Pivot and Fabienne Mougin

    BMC Cancer 2017 17:425

    Published on: 19 June 2017

  17. Research article

    African-American esophageal squamous cell carcinoma expression profile reveals dysregulation of stress response and detox networks

    Esophageal carcinoma is the third most common gastrointestinal malignancy worldwide and is largely unresponsive to therapy. African-Americans have an increased risk for esophageal squamous cell carcinoma (ESCC...

    Hayriye Verda Erkizan, Kory Johnson, Svetlana Ghimbovschi, Deepa Karkera, Gregory Trachiotis, Houtan Adib, Eric P. Hoffman and Robert G. Wadleigh

    BMC Cancer 2017 17:426

    Published on: 19 June 2017

  18. Research article

    Breast cancer patient delay in Fukushima, Japan following the 2011 triple disaster: a long-term retrospective study

    Little information is available concerning how patient delay may be affected by mass disasters. The main objectives of the present study are to identify whether there was a post-disaster increase in the risk o...

    Akihiko Ozaki, Shuhei Nomura, Claire Leppold, Masaharu Tsubokura, Tetsuya Tanimoto, Takeru Yokota, Shigehira Saji, Toyoaki Sawano, Manabu Tsukada, Tomohiro Morita, Sae Ochi, Shigeaki Kato, Masahiro Kami, Tsuyoshi Nemoto, Yukio Kanazawa and Hiromichi Ohira

    BMC Cancer 2017 17:423

    Published on: 19 June 2017

  19. Case report

    Anaplastic astrocytoma mimicking progressive multifocal leucoencephalopathy: a case report and review of the overlapping syndromes

    Co-occurrence of multiple sclerosis (MS) and glial tumours (GT) is uncommon although occasionally reported in medical literature. Interpreting the overlapping radiologic and clinical characteristics of glial t...

    Ema Kantorová, Michal Bittšanský, Štefan Sivák, Eva Baranovičová, Petra Hnilicová, Vladimír Nosáľ, Daniel Čierny, Kamil Zeleňák, Wolfgang Brück and Egon Kurča

    BMC Cancer 2017 17:424

    Published on: 19 June 2017

  20. Research article

    Characterization of MicroRNA-200 pathway in ovarian cancer and serous intraepithelial carcinoma of fallopian tube

    Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst form...

    Junzheng Yang, Yilan Zhou, Shu-Kay Ng, Kuan-Chun Huang, Xiaoyan Ni, Pui-Wah Choi, Kathleen Hasselblatt, Michael G. Muto, William R. Welch, Ross S. Berkowitz and Shu-Wing Ng

    BMC Cancer 2017 17:422

    Published on: 17 June 2017

  21. Research article

    What is the impact of local control in Ewing sarcoma: analysis of the first Brazilian collaborative study group – EWING1

    Relapse in localized Ewing sarcoma patients has been a matter of concern regarding poor prognosis. Therefore, we investigated the impact of local control modality (surgery, surgery plus radiotherapy, and radio...

    Ricardo G. Becker, Lauro J. Gregianin, Carlos R. Galia, Reynaldo Jesus-Garcia Filho, Eduardo A. Toller, Gerardo Badell, Suely A. Nakagawa, Alexandre David, André M. Baptista, Eduardo S. Yonamime, Osvaldo A. Serafini, Valter Penna, Julie Francine C. Santos and Algemir L. Brunetto

    BMC Cancer 2017 17:420

    Published on: 15 June 2017

  22. Study protocol

    Effect of transcutaneous electrical stimulation treatment on lower urinary tract symptoms after class III radical hysterectomy in cervical cancer patients: study protocol for a multicentre, randomized controlled trial

    Class III radical hysterectomy (RH III)_plus pelvic lymphadenectomy is the standard surgery for early stage cervical cancer (CC) patients, the 5 year survival rate is about 90%, but pelvic floor disorders espe...

    Xiu-Li Sun, Hai-Bo Wang, Zhi-Qi Wang, Ting-ting Cao, Xin Yang, Jing-Song Han, Yang-feng Wu, Kathleen H. Reilly and Jian-Liu Wang

    BMC Cancer 2017 17:416

    Published on: 15 June 2017

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