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  1. Research article

    Real-life clinical practice results with vinflunine in patients with relapsed platinum-treated metastatic urothelial carcinoma: an Italian multicenter study (MOVIE-GOIRC 01–2014)

    Vinflunine is the only chemotherapeutic agent shown to improve survival in platinum-refractory patients with metastatic transitional cell carcinoma of the urothelium (TCCU) in a phase III clinical trial, which...

    Rodolfo Passalacqua, Silvia Lazzarelli, Maddalena Donini, Rodolfo Montironi, Rosa Tambaro, Ugo De Giorgi, Sandro Pignata, Raffaella Palumbo, Giovanni Luca Ceresoli, Gianluca Del Conte, Giuseppe Tonini, Franco Morelli, Franco Nolè, Stefano Panni, Ermanno Rondini, Annalisa Guida…

    BMC Cancer 2017 17:493

    Published on: 19 July 2017

  2. Research article

    Tamoxifen reverses epithelial–mesenchymal transition by demethylating miR-200c in triple-negative breast cancer cells

    Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM als...

    Qian Wang, Yu Cheng, Yan Wang, Yibo Fan, Ce Li, Ye Zhang, Yiding Wang, Qian Dong, Yanju Ma, Yue-e Teng, Xiujuan Qu and Yunpeng Liu

    BMC Cancer 2017 17:492

    Published on: 19 July 2017

  3. Study protocol

    Psychosocial and behavioral impact of breast cancer risk assessed by testing for common risk variants: protocol of a prospective study

    The ‘common variant, common disease’ model predicts that a significant component of hereditary breast cancer unexplained by pathogenic variants in moderate or high-penetrance genes is due to the cumulative eff...

    Tatiane Yanes, Bettina Meiser, Mary-Anne Young, Rajneesh Kaur, Gillian Mitchell, Kristine Barlow-Stewart, Tony Roscioli, Jane Halliday and Paul James

    BMC Cancer 2017 17:491

    Published on: 18 July 2017

  4. Research article

    Identification of an easy to use 3D culture model to investigate invasion and anticancer drug response in chondrosarcomas

    Cytotoxic efficacy of anticancer drugs has been widely studied with monolayer-cultured cancer cells. However, the efficacy of drugs under two-dimensional (2D) culture condition usually differs from that of thr...

    Eva Lhuissier, Céline Bazille, Juliette Aury-Landas, Nicolas Girard, Julien Pontin, Martine Boittin, Karim Boumediene and Catherine Baugé

    BMC Cancer 2017 17:490

    Published on: 18 July 2017

  5. Research article

    Quantitation of DNA methylation in Epstein-Barr virus–associated nasopharyngeal carcinoma by bisulfite amplicon sequencing

    Epigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and is highly ass...

    Weilin Zhao, Yingxi Mo, Shumin Wang, Kaoru Midorikawa, Ning Ma, Yusuke Hiraku, Shinji Oikawa, Guangwu Huang, Zhe Zhang, Mariko Murata and Kazuhiko Takeuchi

    BMC Cancer 2017 17:489

    Published on: 17 July 2017

  6. Research article

    β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells

    Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cells (CSCs), thought to be largely responsible for tumor initiation, main...

    Evelina Miele, Agnese Po, Federica Begalli, Laura Antonucci, Angela Mastronuzzi, Carlo Efisio Marras, Andrea Carai, Danilo Cucchi, Luana Abballe, Zein Mersini Besharat, Giuseppina Catanzaro, Paola Infante, Lucia Di Marcotullio, Gianluca Canettieri, Enrico De Smaele, Isabella Screpanti…

    BMC Cancer 2017 17:488

    Published on: 17 July 2017

  7. Research article

    Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

    The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in...

    Chatarina Larsson, Muhammad Akhtar Ali, Tatjana Pandzic, Anders M. Lindroth, Liqun He and Tobias Sjöblom

    BMC Cancer 2017 17:487

    Published on: 17 July 2017

  8. Study protocol

    Chemoradiation in elderly esophageal cancer patients: rationale and design of a phase I/II multicenter study (OSAGE)

    The management of elderly patients with cancer is a therapeutic challenge and a public health problem. Definitive chemoradiotherapy (CRT) is an accepted standard treatment for patients with locally advanced es...

    Stéphanie Servagi-Vernat, Gilles Créhange, Franck Bonnetain, Cécile Mertens, Etienne Brain and Jean François Bosset

    BMC Cancer 2017 17:483

    Published on: 13 July 2017

  9. Research article

    A novel algorithm for the treatment strategy for advanced epithelial ovarian cancer: consecutive imaging, frailty assessment, and diagnostic laparoscopy

    This study aimed to evaluate the perioperative outcomes and prognostic impact of the consecutive steps of imaging, frailty assessment, and diagnostic laparoscopy (DLS) in patients with advanced epithelial ovar...

    Kyung Jin Eoh, Jung Won Yoon, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    BMC Cancer 2017 17:481

    Published on: 12 July 2017

  10. Study protocol

    Long-term effects and psychological adjustment: study protocol of a large register-based study on quality of life among survivors of hematological malignancies

    Both incidence and survival rates of hematological cancers are increasing, leading to a growing number of survivors with specific late and long-term effects. However, relevant research in physical, psychologic...

    Peter Esser, Katharina Kuba, Heide Götze and Anja Mehnert

    BMC Cancer 2017 17:482

    Published on: 12 July 2017

  11. Research article

    Joint quantitative measurement of hTERT mRNA in both peripheral blood and circulating tumor cells of patients with nasopharyngeal carcinoma and its clinical significance

    The study was aimed to quantitatively detect mRNA levels of the catalytic subunit of telomerase (hTERT) in both peripheral blood and circulating tumor cells (CTCs) of patients with nasopharyngeal carcinoma (NP...

    Xinsa Fu, Congxiang Shen, Huigang Wang, Fang Chen, Guanxue Li and Zhong Wen

    BMC Cancer 2017 17:479

    Published on: 11 July 2017

  12. Research article

    JMJD2A promotes the Warburg effect and nasopharyngeal carcinoma progression by transactivating LDHA expression

    Jumonji C domain 2A (JMJD2A), as a histone demethylases, plays a vital role in tumorigenesis and progression. But, its functions and underlying mechanisms of JMJD2A in nasopharyngeal carcinoma (NPC) metabolism...

    Yi Su, Qiu-hong Yu, Xiang-yun Wang, Li-ping Yu, Zong-feng Wang, Ying-chun Cao and Jian-dong Li

    BMC Cancer 2017 17:477

    Published on: 11 July 2017

  13. Research article

    High cancer mortality for US-born Latinos: evidence from California and Texas

    Latinos born in the US, 36 million, comprise 65% of all US Latinos. Yet their cancer experience is nearly always analyzed together with their foreign-born counterparts, 19 million, who constitute a steady infl...

    Paulo S. Pinheiro, Karen E. Callahan, Scarlett Lin Gomez, Rafael Marcos-Gragera, Taylor R. Cobb, Aina Roca-Barcelo and Amelie G. Ramirez

    BMC Cancer 2017 17:478

    Published on: 11 July 2017

  14. Research article

    Proteomic characterization of paired non-malignant and malignant African-American prostate epithelial cell lines distinguishes them by structural proteins

    While many factors may contribute to the higher prostate cancer incidence and mortality experienced by African-American men compared to their counterparts, the contribution of tumor biology is underexplored du...

    Jennifer S. Myers, Karin A. Vallega, Jason White, Kaixian Yu, Clayton C. Yates and Qing-Xiang Amy Sang

    BMC Cancer 2017 17:480

    Published on: 11 July 2017

  15. Study protocol

    Multiparametric magnetic resonance imaging in mucosal primary head and neck cancer: a prospective imaging biomarker study

    Radical radiotherapy, with or without concomitant chemotherapy forms the mainstay of organ preservation approaches in mucosal primary head and neck cancer. Despite technical advances in cancer imaging and radi...

    Christopher N Rumley, Mark T Lee, Lois Holloway, Robba Rai, Myo Min, Dion Forstner, Allan Fowler and Gary Liney

    BMC Cancer 2017 17:475

    Published on: 10 July 2017

  16. Study protocol

    Communication about uncertainty and hope: A randomized controlled trial assessing the efficacy of a communication skills training program for physicians caring for cancer patients

    Although previous studies have reported the efficacy of communication skills training (CST) programs, specific training addressing communication about uncertainty and hope in oncology has not yet been studied....

    Yves Libert, Livia Peternelj, Isabelle Bragard, Aurore Liénard, Isabelle Merckaert, Christine Reynaert and Darius Razavi

    BMC Cancer 2017 17:476

    Published on: 10 July 2017

  17. Research article

    The effects of the location of cancer stem cell marker CD133 on the prognosis of hepatocellular carcinoma patients

    CD133 (prominin-1) is widely believed to be a cancer stem cell marker in various solid tumor types, and CD133 has been correlated with tumor-initiating capacity. Recently, the nuclear location of CD133 express...

    Yao-Li Chen, Ping-Yi Lin, Ying-Zi Ming, Wei-Chieh Huang, Rong-Fu Chen, Po-Ming Chen and Pei-Yi Chu

    BMC Cancer 2017 17:474

    Published on: 7 July 2017

  18. Case report

    ALK-rearranged lung squamous cell carcinoma responding to alectinib: a case report and review of the literature

    Although anaplastic lymphoma kinase (ALK) fusion genes are generally identified in lung adenocarcinoma patients, they are relatively rare in patients with squamous cell carcinoma (SqCC). Metastatic ALK-rearranged...

    Nobuaki Mamesaya, Kazuhisa Nakashima, Tateaki Naito, Takashi Nakajima, Masahiro Endo and Toshiaki Takahashi

    BMC Cancer 2017 17:471

    Published on: 6 July 2017

  19. Research article

    Evolution of educational inequalities in site-specific cancer mortality among Belgian men between the 1990s and 2000s using a “fundamental cause” perspective

    According to the “fundamental cause” theory, emerging knowledge on health-enhancing behaviours and technologies results in health disparities. This study aims to assess (trends in) educational inequalities in ...

    Katrien Vanthomme, Hadewijch Vandenheede, Paulien Hagedoorn and Sylvie Gadeyne

    BMC Cancer 2017 17:470

    Published on: 5 July 2017

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