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Fig. 3 | BMC Cancer

Fig. 3

From: Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area

Fig. 3

Distribution of PLP variants in the functional domains of BRCA1 and BRCA2. Lollipop plot illustrating the frequency of PLP variants across the functional domain of BRCA1 [zinc finger, serine cluster, BRCA1 C-terminus (BRCT)] and BRCA2 [BRC repeats, DNA binding, and nuclear localization signals (NLS)]. The blue circles denote the frequency of PLPs found in the healthy individuals and the orange circles denote PLPs found in BRCA mutation related-cancer carriers. PLP variants were clustered in the BRC repeats and DNA binding domain in cancer patients in comparison to the healthy individuals, but not in NLS domain of BRCA2 and any functional domain of BRCA1

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BMC Cancer

ISSN: 1471-2407

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