Correction: Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000

  • Kenji Shibuya1Email author,

    Affiliated with

    • Colin D Mathers1,

      Affiliated with

      • Cynthia Boschi-Pinto2,

        Affiliated with

        • Alan D Lopez3 and

          Affiliated with

          • Christopher JL Murray4

            Affiliated with

            BMC Cancer20033:20

            DOI: 10.1186/1471-2407-3-20

            Received: 17 July 2003

            Accepted: 23 July 2003

            Published: 23 July 2003

             

            After the publication of this work [1], we noticed the typographical errors in Tables 8, 9, 16, and 17: there were inconsistencies between the ranking of cancer mortality and incidence and their corresponding figures. Here we briefly present the results along with the revisions of the relevant tables since the ranking was corrected while the figures remained the same as the original.

            Tables 1 and 2 represent the ranking of the number of deaths by cancer site in the world and three selected sub regions: African Region with a high child and adult mortality (AfrE), European Region with a very low child and adult mortality (EurA), and South East Asia Region with a low child and adult mortality (SearB). Lung cancer was the leading cause of cancer deaths in the world, accounting for 17% of total cancer mortality, followed by cancers of stomach (12% of total), colon and rectum (9%), liver (9%), and breast (7%). In males, lung, stomach, and liver cancers were the three most common causes of cancer deaths. The leading cause of cancer deaths among females was breast cancer, but lung cancer was already one of the largest causes of female cancer mortality.
            Table 1

            Ranking of the global cancer deaths by site, 2000

            Site

            Number of deaths (000s)

            Proporion of total (%)

            Both sexes

              

            Trachea, bronchus, and lung

            1,201.1

            17.1

            Stomach

            836.2

            11.9

            Colon and rectum

            607.3

            8.7

            Liver

            605.9

            8.6

            Breast

            468.9

            6.7

            Oesophagus

            431.2

            6.1

            Lymphomas and multiple myeloma

            332.3

            4.7

            Mouth and oropharynx

            319.6

            4.6

            Prostate

            263.6

            3.8

            Leukaemia

            260.1

            3.7

            Cervix uteri

            259.6

            3.7

            Pancreas

            222.6

            3.2

            Bladder

            177.4

            2.5

            Ovary

            128.6

            1.8

            Corpus uteri

            72.9

            1.0

            Melanoma of the skin

            65.1

            0.9

            Males

              

            Trachea, bronchus, and lung

            877.3

            22.5

            Stomach

            512.0

            13.2

            Liver

            414.9

            10.7

            Colon and rectum

            311.8

            8.0

            Oesophagus

            273.6

            7.0

            Prostate

            263.6

            6.8

            Mouth and oropharynx

            222.4

            5.7

            Lymphomas and multiple myeloma

            168.6

            4.3

            Leukaemia

            145.3

            3.7

            Bladder

            123.9

            3.2

            Pancreas

            117.0

            3.0

            Melanoma of the skin

            35.1

            0.9

            Females

              

            Breast

            466.3

            14.9

            Stomach

            324.2

            10.4

            Trachea, bronchus, and lung

            323.8

            10.4

            Colon and rectum

            295.5

            9.4

            Cervix uteri

            259.6

            8.3

            Liver

            191.0

            6.1

            Lymphomas and multiple myeloma

            163.7

            5.2

            Oesophagus

            157.6

            5.0

            Ovary

            128.6

            4.1

            Leukaemia

            114.7

            3.7

            Pancreas

            105.6

            3.4

            Mouth and oropharynx

            97.2

            3.1

            Corpus uteri

            72.9

            2.3

            Bladder

            53.5

            1.7

            Melanoma of the skin

            30.1

            1.0

            Table 2

            Ranking of selected regional cancer deaths by site, 2000

            WHO sub region

            AfrE (high child and adult mortality)

            EurA (very low child and adult mortality)

            SearB (low child and adult mortality)

            Site

            Number of deaths (000s)

            Proportion of total (%)

             

            Number of deaths (000s)

            Proportion of total (%)

             

            Number of deaths (000s)

            Proportion of total (%)

            Both sexes

                    

            Cervix uteri

            36.8

            12.4

            Trachea, bronchus, and lung

            207.2

            19.5

            Trachea, bronchus, and lung

            48.3

            16.6

            Liver

            33.3

            11.2

            Colon and rectum

            141.8

            13.3

            Liver

            36.5

            12.5

            Breast

            23.0

            7.8

            Breast

            92.7

            8.7

            Breast

            29.1

            10.0

            Mouth and oropharynx

            21.4

            7.2

            Prostate

            70.2

            6.6

            Colon and rectum

            27.6

            9.5

            Oesophagus

            20.6

            7.0

            Stomach

            66.8

            6.3

            Mouth and oropharynx

            18.6

            6.4

            Prostate

            19.2

            6.5

            Lymphomas and multiple myeloma

            55.0

            5.2

            Lymphomas and multiple myeloma

            15.8

            5.4

            Lymphomas and multiple myeloma

            18.8

            6.4

            Pancreas

            53.6

            5.0

            Cervix uteri

            15.4

            5.3

            Stomach

            17.0

            5.7

            Liver

            38.6

            3.6

            Leukaemia

            14.7

            5.1

            Colon and rectum

            14.1

            4.8

            Bladder

            37.6

            3.5

            Stomach

            12.5

            4.3

            Trachea, bronchus, and lung

            14.0

            4.7

            Leukaemia

            37.3

            3.5

            Ovary

            8.7

            3.0

            Leukaemia

            11.8

            4.0

            Oesophagus

            29.2

            2.7

            Prostate

            8.1

            2.8

            Ovary

            6.7

            2.3

            Ovary

            25.7

            2.4

            Pancreas

            6.8

            2.3

            Bladder

            6.3

            2.1

            Mouth and oropharynx

            24.9

            2.3

            Bladder

            5.8

            2.0

            Melanoma of the skin

            5.3

            1.8

            Corpus uteri

            16.0

            1.5

            Oesophagus

            5.6

            1.9

            Pancreas

            5.2

            1.8

            Melanoma of the skin

            15.5

            1.5

            Corpus uteri

            4.0

            1.4

            Corpus uteri

            1.7

            0.6

            Cervix uteri

            8.3

            0.8

            Melanoma of the skin

            1.7

            0.6

            Males

                    

            Liver

            23.5

            15.2

            Trachea, bronchus, and lung

            158.0

            26.6

            Trachea, bronchus, and lung

            40.8

            26.4

            Prostate

            19.2

            12.5

            Colon and rectum

            72.1

            12.1

            Liver

            25.9

            16.7

            Mouth and oropharynx

            14.3

            9.3

            Prostate

            70.2

            11.8

            Colon and rectum

            13.9

            9.0

            Oesophagus

            13.8

            8.9

            Stomach

            38.9

            6.5

            Mouth and oropharynx

            13.1

            8.4

            Lymphomas and multiple myeloma

            13.7

            8.9

            Lymphomas and multiple myeloma

            27.6

            4.6

            Lymphomas and multiple myeloma

            9.6

            6.2

            Stomach

            9.8

            6.3

            Bladder

            27.1

            4.6

            Prostate

            8.1

            5.3

            Trachea, bronchus, and lung

            9.4

            6.1

            Pancreas

            26.7

            4.5

            Leukaemia

            7.6

            4.9

            Colon and rectum

            8.8

            5.7

            Liver

            25.3

            4.3

            Stomach

            7.1

            4.6

            Leukaemia

            6.9

            4.5

            Oesophagus

            21.4

            3.6

            Bladder

            4.4

            2.8

            Bladder

            4.3

            2.8

            Leukaemia

            20.0

            3.4

            Pancreas

            3.5

            2.3

            Pancreas

            2.7

            1.8

            Mouth and oropharynx

            19.2

            3.2

            Oesophagus

            3.3

            2.1

            Melanoma of the skin

            2.2

            1.5

            Melanoma of the skin

            8.3

            1.4

            Melanoma of the skin

            0.7

            0.5

            Females

                    

            Cervix uteri

            36.8

            26.0

            Breast

            91.8

            19.6

            Breast

            29.0

            21.2

            Breast

            23.0

            16.3

            Colon and rectum

            69.7

            14.9

            Cervix uteri

            15.4

            11.2

            Liver

            9.8

            6.9

            Trachea, bronchus, and lung

            49.2

            10.5

            Colon and rectum

            13.6

            10.0

            Stomach

            7.2

            5.1

            Stomach

            27.9

            6.0

            Liver

            10.6

            7.8

            Mouth and oropharynx

            7.1

            5.0

            Lymphomas and multiple myeloma

            27.4

            5.9

            Ovary

            8.7

            6.3

            Oesophagus

            6.8

            4.8

            Pancreas

            26.9

            5.8

            Trachea, bronchus, and lung

            7.5

            5.5

            Ovary

            6.7

            4.8

            Ovary

            25.7

            5.5

            Leukaemia

            7.2

            5.2

            Colon and rectum

            5.3

            3.7

            Leukaemia

            17.2

            3.7

            Lymphomas and multiple myeloma

            6.1

            4.5

            Lymphomas and multiple myeloma

            5.2

            3.7

            Corpus uteri

            16.0

            3.4

            Mouth and oropharynx

            5.5

            4.0

            Leukaemia

            4.9

            3.5

            Liver

            13.3

            2.8

            Stomach

            5.5

            4.0

            Trachea, bronchus, and lung

            4.5

            3.2

            Bladder

            10.5

            2.2

            Corpus uteri

            4.0

            2.9

            Melanoma of the skin

            3.0

            2.1

            Cervix uteri

            8.3

            1.8

            Pancreas

            3.3

            2.4

            Pancreas

            2.5

            1.8

            Oesophagus

            7.8

            1.7

            Oesophagus

            2.3

            1.7

            Bladder

            2.0

            1.4

            Melanoma of the skin

            7.2

            1.5

            Bladder

            1.4

            1.0

            Corpus uteri

            1.7

            1.2

            Mouth and oropharynx

            5.7

            1.2

            Melanoma of the skin

            1.0

            0.7

            The distribution of common cancer incidence was somewhat similar to that of mortality: lung cancer was the most common cancer in the world in 2000, accounting for 13% of total cancer incidence, followed by cancers of colon and rectum (10% of total), breast (10%), stomach (10%), and liver (6%) (Table 3). As in mortality distribution, there is a significant variation in the distribution of site-specific cancer incidence by region (Table 4). The variations in the distribution of site-specific new cases of cancer by region were also similar to those observed in mortality distribution.
            Table 3

            Ranking of the global cancer incidence by site, 2000

            Site

            Number of new cases (000s)

            Proportion of total (%)

            Both sexes

              

            Trachea, bronchus and lung

            1,305.6

            12.7

            Colon and rectum

            1,045.0

            10.2

            Breast

            1,031.9

            10.0

            Stomach

            973.1

            9.5

            Liver

            626.4

            6.1

            Prostate

            550.2

            5.3

            Cervix uteri

            487.5

            4.7

            Lymphomas and multiple myeloma

            481.1

            4.7

            Oesophagus

            452.7

            4.4

            Mouth and oropharynx

            420.7

            4.1

            Bladder

            382.9

            3.7

            Leukaemia

            364.7

            3.5

            Corpus uteri

            326.3

            3.2

            Pancreas

            226.2

            2.2

            Ovary

            221.3

            2.2

            Melanoma of the skin

            206.7

            2.0

            Males

              

            Trachea, bronchus and lung

            939.9

            18.2

            Stomach

            589.3

            11.4

            Prostate

            550.2

            10.6

            Colon and rectum

            527.8

            10.2

            Liver

            422.0

            8.2

            Oesophagus

            286.5

            5.5

            Bladder

            277.2

            5.4

            Mouth and oropharynx

            267.1

            5.2

            Lymphomas and multiple myeloma

            238.5

            4.6

            Leukaemia

            195.2

            3.8

            Pancreas

            119.3

            2.3

            Melanoma of the skin

            118.2

            2.3

            Females

              

            Breast

            1,031.9

            20.1

            Colon and rectum

            517.3

            10.1

            Cervix uteri

            487.5

            9.5

            Stomach

            383.9

            7.5

            Trachea, bronchus and lung

            365.7

            7.1

            Corpus uteri

            326.3

            6.4

            Lymphomas and multiple myeloma

            242.6

            4.7

            Ovary

            221.3

            4.3

            Liver

            204.4

            4.0

            Leukaemia

            169.5

            3.3

            Oesophagus

            166.2

            3.2

            Mouth and oropharynx

            153.6

            3.0

            Pancreas

            106.9

            2.1

            Bladder

            105.7

            2.1

            Melanoma of the skin

            88.5

            1.7

            Table 4

            Ranking of the selected regional cancer incidence by site, 2000

            WHO sub region

            AfrE (high child and adult mortality)

            EurA (very low child and adult mortality)

            SearB (low child and adult mortality)

            Site

            Number of new cases (000s)

            Proportion of total (%)

            Site

            Number of new cases (000s)

            Proportion of total (%)

            Site

            Number of new cases (000s)

            Proportion of total (%)

            Both sexes

                    

            Cervix uteri

            67.9

            16.4

            Colon and rectum

            264.7

            15.4

            Breast

            53.9

            12.3

            Breast

            39.8

            9.6

            Trachea, bronchus and lung

            227.3

            13.2

            Trachea, bronchus and lung

            51.4

            11.7

            Liver

            34.7

            8.3

            Breast

            221.8

            12.9

            Colon and rectum

            44.3

            10.1

            Prostate

            28.2

            6.8

            Prostate

            139.1

            8.1

            Liver

            40.3

            9.2

            Mouth and oropharynx

            27.9

            6.7

            Bladder

            86.5

            5.0

            Cervix uteri

            32.8

            7.5

            Lymphomas and multiple myeloma

            26.6

            6.4

            Lymphomas and multiple myeloma

            80.2

            4.7

            Mouth and oropharynx

            25.4

            5.8

            Oesophagus

            21.2

            5.1

            Stomach

            79.6

            4.6

            Lymphomas and multiple myeloma

            22.9

            5.2

            Colon and rectum

            20.3

            4.9

            Corpus uteri

            68.3

            4.0

            Leukaemia

            21.5

            4.9

            Stomach

            19.4

            4.7

            Pancreas

            55.5

            3.2

            Corpus uteri

            19.9

            4.5

            Leukaemia

            16.2

            3.9

            Melanoma of the skin

            49.1

            2.8

            Ovary

            18.1

            4.1

            Trachea, bronchus and lung

            14.8

            3.6

            Leukaemia

            48.6

            2.8

            Stomach

            15.3

            3.5

            Ovary

            12.2

            2.9

            Liver

            40.1

            2.3

            Prostate

            13.4

            3.1

            Bladder

            10.7

            2.6

            Ovary

            39.4

            2.3

            Bladder

            10.1

            2.3

            Melanoma of the skin

            7.7

            1.8

            Mouth and oropharynx

            38.6

            2.2

            Pancreas

            7.2

            1.7

            Corpus uteri

            6.0

            1.4

            Oesophagus

            31.2

            1.8

            Oesophagus

            6.2

            1.4

            Pancreas

            5.4

            1.3

            Cervix uteri

            18.8

            1.1

            Melanoma of the skin

            3.1

            0.7

            Male

              

            Male

              

            Male

              

            Prostate

            28.2

            14.8

            Trachea, bronchus and lung

            172.0

            19.6

            Trachea, bronchus and lung

            43.1

            22.0

            Liver

            23.6

            12.4

            Prostate

            139.1

            15.9

            Liver

            28.6

            14.6

            Lymphomas and multiple myeloma

            18.6

            9.8

            Colon and rectum

            133.8

            15.3

            Colon and rectum

            21.4

            11.0

            Mouth and oropharynx

            16.5

            8.7

            Bladder

            65.1

            7.4

            Mouth and oropharynx

            16.0

            8.2

            Oesophagus

            14.1

            7.4

            Stomach

            45.6

            5.2

            Prostate

            13.4

            6.9

            Colon and rectum

            12.0

            6.3

            Lymphomas and multiple myeloma

            39.3

            4.5

            Lymphomas and multiple myeloma

            13.3

            6.8

            Stomach

            10.9

            5.8

            Mouth and oropharynx

            28.7

            3.3

            Leukaemia

            10.7

            5.5

            Trachea, bronchus and lung

            9.8

            5.2

            Pancreas

            27.4

            3.1

            Stomach

            8.6

            4.4

            Leukaemia

            9.2

            4.9

            Liver

            26.1

            3.0

            Bladder

            7.7

            3.9

            Bladder

            7.3

            3.8

            Leukaemia

            25.6

            2.9

            Oesophagus

            3.8

            1.9

            Melanoma of the skin

            3.4

            1.8

            Oesophagus

            22.8

            2.6

            Pancreas

            3.7

            1.9

            Pancreas

            2.8

            1.5

            Melanoma of the skin

            22.6

            2.6

            Melanoma of the skin

            1.2

            0.6

            Female

              

            Female

              

            Female

              

            Cervix uteri

            67.9

            30.2

            Breast

            221.8

            26.2

            Breast

            53.9

            22.3

            Breast

            39.8

            17.7

            Colon and rectum

            131.0

            15.4

            Cervix uteri

            32.8

            13.6

            Ovary

            12.2

            5.4

            Corpus uteri

            68.3

            8.1

            Colon and rectum

            22.8

            9.4

            Mouth and oropharynx

            11.4

            5.1

            Trachea, bronchus and lung

            55.3

            6.5

            Corpus uteri

            19.9

            8.2

            Liver

            11.1

            4.9

            Lymphomas and multiple myeloma

            40.9

            4.8

            Ovary

            18.1

            7.5

            Stomach

            8.4

            3.7

            Ovary

            39.4

            4.6

            Liver

            11.7

            4.8

            Colon and rectum

            8.2

            3.7

            Stomach

            33.9

            4.0

            Leukaemia

            10.8

            4.5

            Lymphomas and multiple myeloma

            8.0

            3.6

            Pancreas

            28.1

            3.3

            Lymphomas and multiple myeloma

            9.6

            4.0

            Oesophagus

            7.2

            3.2

            Melanoma of the skin

            26.5

            3.1

            Mouth and oropharynx

            9.4

            3.9

            Leukaemia

            7.0

            3.1

            Leukaemia

            23.0

            2.7

            Trachea, bronchus and lung

            8.3

            3.4

            Corpus uteri

            6.0

            2.7

            Bladder

            21.4

            2.5

            Stomach

            6.7

            2.8

            Trachea, bronchus and lung

            5.0

            2.2

            Cervix uteri

            18.8

            2.2

            Pancreas

            3.6

            1.5

            Melanoma of the skin

            4.3

            1.9

            Liver

            14.0

            1.7

            Oesophagus

            2.5

            1.0

            Bladder

            3.4

            1.5

            Mouth and oropharynx

            9.9

            1.2

            Bladder

            2.4

            1.0

            Pancreas

            2.6

            1.2

            Oesophagus

            8.4

            1.0

            Melanoma of the skin

            1.9

            0.8

            We regret any inconvenience that this inaccuracy in the tables might have caused. We wish to thank Dr. Robert Dubrow of Yale University School of Medicine for bringing this matter to our attention.

            Authors’ Affiliations

            (1)
            Global Program on Evidence for Health Policy, World Health Organization
            (2)
            Family and Community Health/Child and Adolescent Health and Development, World Health Organization
            (3)
            School of Population Health, University of Queensland
            (4)
            Executive Director, Evidence and Information for Policy, World Health Organization

            References

            1. Shibuya K, Mathers CD, Boschi-Pinto C, Lopez AD, Murray CJL: Global and regional estimates of cancer mortality and incidence by site: II. results for the global burden of disease 2000. BMC Cancer 2002, 2: 37.View ArticlePubMed
            2. Pre-publication history

              1. The pre-publication history for this paper can be accessed here:http://​www.​biomedcentral.​com/​1471-2407/​3/​20/​prepub

            Copyright

            © Shibuya et al 2003

            This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.

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