Time trends in municipal distribution patterns of cancer mortality in Spain
© López-Abente et al.; licensee BioMed Central Ltd. 2014
Received: 6 February 2014
Accepted: 4 July 2014
Published: 24 July 2014
New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health. This paper reports on trends in the geographical mortality patterns of the most frequent cancers in Spain, over a period of 20 years.
We studied the municipal spatial pattern of stomach, colorectal, lung, breast, prostate and urinary bladder cancer mortality in Spain across four quinquennia, spanning the period 1989-2008. Case data were broken down by town (8073 municipalities), period and sex. Expected cases for each town were calculated using reference rates for each five-year period. For map plotting purposes, smoothed municipal relative risks were calculated using the conditional autoregressive model proposed by Besag, York and Mollié, with independent data for each quinquennium. We evaluated the presence of spatial patterns in maps on the basis of models, calculating the variance in relative risk corresponding to the structured spatial component and the unstructured component, as well as the proportion of variance explained by the structured spatial component.
The mortality patterns observed for stomach, colorectal and lung cancer were maintained over the 20 years covered by the study. Prostate cancer and the tumours studied in women showed no defined spatial pattern, with the single exception of stomach cancer. The trend in spatial fractional variance indicated the possibility of a change in the spatial pattern in breast, bladder and colorectal cancer in women during the last five-year period. The paper goes on to discuss ways in which spatio-temporal data are depicted in the case of cancer, and review the risk factors that may possibly influence the respective tumours’ spatial patterns.
In men, the marked geographical patterns of stomach, colorectal, lung and bladder cancer remained stable over time. Breast, colorectal and bladder cancer in women show signs of the possible appearance of a spatial pattern in Spain and should therefore be monitored.
KeywordsDisease mapping Cancer mortality Epidemiology Spatial epidemiology
New disease mapping techniques widely used in small-area studies enable disease distribution patterns to be identified and have become extremely popular in the field of public health [1, 2]. Cancer and other disease mortality atlases [3–5] have shown that many risk factors of a territorial (and thus of an environmental) nature, influence geographical patterns. New methods of analysis make it possible to smooth selected disease indicators and so reveal their geographical structure . Estimators obtained in less populated areas share information with neighbouring areas, assuming that they are exposed to common environmental factors. Yet, disease incidence and mortality are dynamic processes and therefore variable in space and time. As a result, different spatio-temporal disease mapping techniques have recently been proposed without any broad consensus as to how to describe spatio-temporal disease trends [7–11].
The aim of this study was to report on trends in geographical mortality patterns of the most frequent cancers in Spain across four quinquennia, and in so doing, update the information published in previous studies [12–14].
As our case source, we used individual death entries for the period 1989-2008 corresponding to stomach cancer (International Classification of Diseases, Ninth Revision (ICD-9) code 151, ICD-10 C16), colorectal cancer (ICD- 9 codes 153-154, 159.0, ICD-10 code C18-C21), lung cancer (ICD- 9 code 162, ICD-10 code C33-C34), breast cancer in women (ICD- 9 code 174, ICD-10 code C50), prostate (ICD- 9 code 185, ICD-10 code C61) and bladder cancer (ICD- 9 code 188, ICD-10 code C67). These data were furnished by the National Statistics Institute (Instituto Nacional de Estadística - INE). The observed case data were broken down by town (8073 municipalities) and sex. Municipal populations, with a breakdown by age group (18 groups) and sex, were obtained from the 1991 and 2001 censuses and the 1996 and 2006 municipal rolls, official information provided by INE. These years corresponded to the midpoints of the four quinquennia comprising the study period (1989-1993, 1994-1998, 1999-2003 and 2004-2008). The person-years for each five-year period were obtained by multiplying these populations by 5.
To calculate expected cases, the overall Spanish mortality rates for the above four 5-year periods were multiplied by each town’s person-years, by age group and quinquennium. Standardised mortality ratios (SMRs) were calculated as the ratio of observed to expected deaths.
The smoothed RRs for plotting purposes are (ζ i = exp(υi + νi)). A separate model was fitted for each period.
Lastly, in order to have an indicator of the presence of a spatial pattern in the mortality plotted for the respective cancers, we estimated the variance in relative risk corresponding to the structured spatial component and the unstructured component, as well as the proportion of variance explained by the structured spatial component .
Integrated nested Laplace approximations (INLAs) were used as a tool for Bayesian inference. For this purpose, we used R-INLA  with the option of simplified Laplace estimation of the parameters, a package available in the R environment . A total of 8073 towns were included, and the spatial data on municipal contiguities was obtained by processing the official INE maps.
Examples of R scripts describing the models used to obtain the relative risk smoothed maps and the calculation of the components of the variance of spatial terms have been published elsewhere .
Deaths & age-adjusted rates (x 100,000) by sex, period and cancer site in Spain
During the period 1989-2008, there were 104,955 deaths due to prostate cancer in Spain, accounting for 10% of mortality due to all malignant tumours in men. The prostate cancer mortality pattern was not at all pronounced (Figure 5 down), indicating -as in the case of breast cancer among women- territorial uniformity in exposure to possible risk factors. A south-north pattern was in evidence during the first three quinquennia. Galicia was the area having the highest number of towns with excess risk. In Andalusia, which had registered lower than expected mortality in the first three quinquennia, a change seemed to be taking place in the period 2004-2008 in the provinces of Huelva and Cadiz, which began to display RRs of over 1.05 in many towns.
Bladder cancer mortality was five times lower among women than among men, with the spatial pattern showing a rather singular trend: in west Andalusia, excess mortality among women was confined to the first five-year period and then disappeared; and, while the pattern displayed by women in towns in Catalonia appeared to level off in the 3rd quinquennium, in the period 2004-2008 there was a resurgence in RRs of over 1.10 in Catalonia and in areas lying in the Pyrenean foothills (Pre-Pyrenees).
Spatial patterns and changes over time
Variance in spatial and heterogeneity components, and proportion of the variance in mortality relative risk explained by the spatial structure of the models
Additional file 1 includes the following information: 1) Probability density functions showing distribution of smoothed relative risks used in each map and 2) Plots showing the evolution of the variance of model spatial and heterogeneity components and the proportion of the mortality relative risk variance explained by the spatial structure of the models.
This study describes the mortality geographical patterns trend across four quinquennia, and so updates the municipal mortality maps previously published for the most frequent malignant tumours in Spain. Generally speaking, the mortality patterns observed for the most frequent cancers of the digestive system (stomach and colorectal) and respiratory tract, appear to be stable over time. In women, the distribution of mortality due to the tumours studied showed no defined spatial patterns, with the single exception of stomach cancer. However, time trends in spatial fractional variance enable the presence of changes in the spatial pattern to be assessed. Among the tumours analysed, breast, bladder and colorectal cancer in women suggest the possible appearance of a spatial pattern in the last quinquennium, a circumstance that will have to be monitored by subsequent studies. Prostate cancer mortality displayed no clear geographical pattern.
Cancer mortality is a dynamic process that is variable in time and space. Yet, the prolonged latency periods that exist between exposure and disease, mean that changes in incidence and/or mortality indicators may occur gradually over time, and their examination requires the incorporation of instruments of spatio-temporal analysis. In recent years, a number of spatio-temporal analysis techniques have been proposed [7–11]. The implementation of these methods is not simple, however, in that their theoretical development is far in advance of that of specific applications. Furthermore, there is no broad consensus as to how to describe spatial and temporal trends simultaneously and appropriately. These techniques’ performance might possibly be very different if they were applied to diseases without long latency periods.
In this study we opted to use separate spatial models for each period. Accordingly, each map shares the spatial data, and the temporal data are solely subject to the constraint of selection of reference rates for each period. This decision was taken after exploring other possibilities, such as plotting the maps by periods obtained on the basis of spatio-temporal models having a common reference rate or specific reference rates for each of the four periods. Each of these approaches has its advantages and disadvantages. The best solution is probably to adapt each method of presentation and modelling to the disease being studied, or to draw conclusions from the results of the different methods of analysis.
In Spain, cancer, both overall and by principal site (lung, colon-rectum, prostate, stomach, pancreas, breast, uterus, brain, leukaemia, lymphomas and myeloma), is well reflected in death certificates. A complete description of the entire process of certification and registration of deaths in Spain and an assessment of the quality of the information have been published elsewhere .
Since the development of a malignant tumour is a slow process, with a long latency period, influenced by many factors, the epidemiology of these tumours cannot be understood without taking into account the interaction between different environmental factors and genetic factors. On the other hand, spatial patterns could reveal differences in risk factors and make a significant contribution to establish policies for the fight against cancer in different areas and population groups.
In Spain (2011), stomach cancer caused 5597 deaths, which accounted for 5.3% of all cancer-related deaths. It is estimated that 7810 new cases were diagnosed in 2012. In Spain, the adjusted incidence rate (European standard population) estimated for 2012 was 16.4 cases per 100,000 population in men (10.8 mortality) and 7.5 in women (4.8 mortality) . In terms of mortality, the rates estimated for this same year were 10.8 per 100,000 population in men and 4.8 in women. The small difference between the incidence and mortality rates is due to the low survival recorded for gastric cancer, which is estimated in Spain to be 27.8% at 5 years, a little above the mean relative survival for Europe as a whole (24.1) . Within Europe, the highest incidence is registered by Central and East European countries, while Nordic countries register the lowest rates for both sexes .
Until a few decades ago, gastric cancer was the most frequent cause of cancer-related death world-wide. Subsequently, albeit at different points in time, incidence and mortality due to this tumour began to decline in all countries during the second half of the 20th century. Despite this decline, this tumour continues to rank fourth in incidence and the second in mortality . Currently, the highest rates are registered in developing countries, and in East Asia in particular .
In Spain, there is a geographical gastric-cancer mortality distribution pattern that is characterised by its persistence in time and, in particular, by its similarity in both sexes. This study shows that the pattern has not changed substantially over the 20 years studied. Although the implication of H. pylori infection in the pattern observed in this country is uncertain, one cannot rule out the implication of different H. pylori strains which circulate in different regions or which circulated in the first half of the 20th century when the generations currently studied were infected (during their infancy). Furthermore, the marked coast-interior pattern might be associated with different dietary habits in more rural areas of the interior, where more cured/smoked foodstuffs and less fruit and vegetables might be consumed than in coastal areas, or with territorially-related environmental exposures.
In order to understand the epidemiology of this tumour the interaction among the factors responsible for the virulence of the micro-organisms implicated, environmental factors and genetic factors  have to be taken into account.
The great geographical variability in this tumour’s mortality in Spain indicates the need to continue studying the factors implicated in the excess risk that is present in some areas, to enable its frequency to be reduced.
In Spain, colorectal cancer accounts for 13.7% of cancer-related deaths in men and 15.8% in women, according to data for the year 2011. Estimates for 2012 put the number of new cases in both sexes at 32,240, and the number of deaths at 14,700 . The two sites are normally analysed jointly due to frequent errors of classification of tumours of the rectosigmoid junction . Mortality is very high, with this constituting the second leading tumour site among men and women alike. From the second half of the 1990s onwards, mortality and incidence in both sexes were seen to level off .
In these tumours, the mortality data do not reflect the true incidence of the disease, since survival has improved in recent years, mainly among the young. In Spain, age-standardised relative survival at five years of diagnosis stands at 53.6% in both sexes, 54.9% if the tumour is located in the colon, and 51.7% if it is situated in the rectum .
In most cases, the aetiology of colorectal cancer is unknown. The frequency of these tumours has been linked to economic development, i.e., unlike the remaining tumours of the digestive system (buccal cavity and pharynx, oesophagus and stomach), it is highest in the most developed countries. Incidence and mortality rates in Spain are similar to the average rates for Europe and West European countries, with the highest rates corresponding to East European countries. In 2006, mortality and incidence were substantially lower in Spain than in North European countries, with Spanish rates being below the average for Europe.
Among the known aetiological factors is genetic predisposition, which would give rise to the presence of familial polyposis with tumours that more frequently turned malignant. Hereditary factors are present in 10% to 15% of cases. Risk factors described in the literature include higher consumption of meat and animal fats, and lower fibre consumption. In addition, a number of cohort studies, case-control studies and meta-analyses published in recent years have confirmed that smoking increases the risk of developing colorectal cancer [24, 25]. Although the results are not very consistent, alcohol consumption has been reported as being a possible risk factor . Reported protective factors include intake of vegetables, fruit, fibre, calcium and some medications [27, 28]. The pathogenic mechanism postulated is the action of intestinal bacteria on biliary acids and fats producing carcinogenic substances. A diet poor in fibre would make for a slower gastrointestinal transit and thereby increase the degree of contact between such carcinogens and the mucosa . Finally there are some studies suggesting that environmental factors like industrial emissions to air might be a risk factor for colorectal cancer [30, 31].
During the last five-year period studied, some Autonomous Regions (Comunidades Autónomas), acting in accordance with European Screening Guidelines , have implemented colorectal cancer screening programmes. This is the case of Catalonia, Valencian Region, Murcia, the Basque Country and Cantabria . Although these programmes can be assumed to have had little or negligible influence on the results shown, they will contribute in the near future to reducing incidence and mortality due to this cause and could influence the spatial pattern of mortality if this practice is not extended to the whole population.
This is the most frequent tumour among men in Spain. In 2011, there were 17,485 male deaths due to this cause, accounting for 28% of all malignant tumours; in women there were 3,577 deaths due to this tumour, accounting for 5% of all cancers. Spain ranks midway in male incidence and mortality with respect to other countries in the region. Female incidence and mortality rates are still among the lowest in Europe, and Denmark has rates that are 4 times higher than those in Spain. Lung cancer prognosis is extremely poor, with relative age-adjusted survival at five years standing at 10.7% in Spain and generally lower in the other European countries .
Age-adjusted mortality rates among men peaked in 1995, with 72.5 cases per 100,000 population, and declined thereafter. Female adjusted rates began to rise at the end of the 1980s, and the trends in specific rates and the cohort effect are radically different to those in men, with a rise in risk being in evidence from the l940-generation onwards. This shows the effect of the smoking habit being taken up by women. The mortality trend is very different to that of other European countries and confirms the onset of the lung cancer epidemic among women in Spain.
Established environmental risk factors for lung cancer include: smoking cigarettes and other tobacco products; exposure to second-hand tobacco smoke; occupational exposure to benzo(a)pyrene and agents such as asbestos, nickel, chromium, and arsenic (inhalation and ingestion); exposure to radiation, including radon gas in homes and mines; and exposure to indoor and outdoor air pollution .
The spatial pattern of lung cancer mortality is assumed to be determined by the prevalence of smokers; any changes in this pattern over time would thus derive from the trend in this prevalence. Yet, visual examination of the spatial pattern shows it to be very similar across the four five-year periods for each sex separately, though a detailed study brings some variations to light. A certain attenuation of the RR would seem to be present among men in towns in west Andalusia. In women, the most notable finding was the excess risk observed for towns in Pontevedra and Ourense (Galicia) across all four quinquennia. This might be related to greater exposure to radon in homes in these areas, since maps of the local natural radiation sites coincide with those areas having the highest levels in Galicia .
Another finding of note was that in the last five-year period, excess risk among women centred on the most urban municipal areas. This excess risk points to provincial capitals and metropolitan areas where the prevalence of smokers is higher than that of rural areas, and where, moreover, the effect of air pollution would also have to be taken into account.
Recently, the International Agency for Research on Cancer (IARC) has concluded that there is sufficient evidence to show that exposure to outdoor air pollution causes lung cancer (Group 1). It has also noted a positive association with increased risk of bladder cancer . Synergism between air pollution and smoking would indicate that the burden of cancer associated with smoking may be far greater than that indicated by the estimated risk attributable to smoking alone .
In Spain, some 26,000 breast cancer cases are diagnosed per year  and lead to the death of around 6000 women. The incidence rate estimated for 2012 was 85 cases per 100,000 women per year (standard European population), very similar to that of countries such as Portugal and Austria . The adjusted mortality rate was 16.7 per 100,000, one of the lowest in Europe. It is estimated that in Spain there are currently more than 100,000 women with breast cancer who have been diagnosed in recent years .
Early detection programmes, together with diagnostic and therapeutic advances, have translated as an increase in survival, which exceeds 80% at five years of diagnosis . Accordingly, mortality has lost validity when it comes to studying the frequency of the appearance of these tumours, though it continues to be the only indicator available for studying geographical variability across the nation. In Spain, breast cancer screening programmes were introduced in the various Autonomous Regions in the 1990s, and by 2001 had attained a coverage of over 90%. The high participation rates in these programmes, which in Spain are population-based, have resulted in a momentary fall in incidence at the point where they reach “saturation” .
The principal known risk factors for breast cancer are age, premature menarchy, late-onset menopause, nulliparity or first pregnancy at late age, exposure to ionizing radiations, presence of mutations in high-penetrance genes (BRCA1, BRCA2 and others), family history , alcohol consumption and obesity in postmenopausal women . Apart from factors linked to genetic susceptibility, the effect of the other risk determinants is explained in terms of cumulative lifetime oestrogen exposure . Exogenous oestrogens also modify risk, with hormone replacement therapy being especially relevant, bearing in mind the point in time at which exposure occurs . However, this type of treatment has been used very little in Spain . Breast cancer describes a positive socio-economic gradient, with incidence and mortality being higher in groups having a higher socio-economic level . This gradient is less evident in recent years, since it is due, in part, to the distribution of risk factors of a hormonal or reproductive nature in the different social levels.
In 2012, Spain, with an estimated rate of 96.8 new cases per 100,000 population, had intermediate incidence rates with respect to Europe, while its mortality rates were the lowest on the continent. Even so, prostate cancer caused close on 1 of every 10 male cancer-related deaths in this country, ranking third, after lung cancer and colorectal tumours, as a tumour-related cause of death in Spanish men. The 2011 mortality rate in Spain was 17.11 deaths per 100,000 population. The mortality rates are considerably lower than the incidence rates, in view of this tumour’s good survival rate, which in Spain is around 75.4% at 5 years .
Prostate cancer incidence has increased in recent years , probably due to non-systematic PSA screening for this tumour. Mortality rates rose until 1995, something that is attributed to improvements in diagnosis and certification of cause of death. In recent years, the trend has become inverted, due to improvements in the survival of these patients. Although the spatial pattern in this tumour is not particularly noteworthy, the maps make it possible to discern a growing uniformity across the country, which means that in the last period there were no observable differences in risk between some regions and others. Indeed, the spatial fractional variance figures are the lowest of all the tumours studied in this analysis.
Neither the agents which cause the appearance of prostate cancer nor those which cause tumours to progress towards a clinically manifest tumour are known. Several polymorphisms associated with a higher risk of developing this cancer have already been identified . Epidemiological, clinical and basic research has suggested that androgens might play an important role in prostatic carcinogenesis . Glucose metabolism might be implicated in this tumour, which would explain why diabetics have a lower risk , and drugs such as statins might also possibly reduce the probability of developing an aggressive tumour . With regard to diet, available information suggests that dairy products could increase prostate cancer risk , whereas foods containing lycopene or selenium might reduce it .
Insofar as the spatial pattern is concerned, none of the risk factors discussed (genetic susceptibility, hormones, diet or consumption of dairy products) is territorially related. Diabetes or the protective factor afforded by oral antidiabetics may perhaps account for the lower prostate cancer mortality observed for Andalusia, since in the period 1989-1998 this region had a higher diabetes-related mortality rate than did the rest of Spain .
In a European context, Spain regrettably occupies a pre-eminent position in terms of this tumour’s incidence (1st country) and mortality (2nd country): in 2011 there were 4,153 bladder cancer-related deaths in men and 931 in women, with the male and female European-population-adjusted mortality rates being 12.81 and 1.95 per 100,000 population respectively. It is estimated that in 2012 there were 13,789 new cases en Spain, with partial prevalence (cases diagnosed in the last 5 years) being very high, i.e., 47,225 cases, ranking 4th after breast, prostate and colorectal cancer. Relative survival for this tumour in Spain at 5 years of diagnosis is 74.09% in men and 72.50% in women, somewhat higher than that for Europe as a whole . This frequency, coupled with the relapsing nature of bladder cancer, means that it place an enormous burden on health care systems [52, 53].
Smoking is recognised as the most important risk factor for bladder cancer and is estimated to account for 50% of tumours. Tobacco smoke contains aromatic amines, such as b-naphthylamine, and polycyclic aromatic hydrocarbons known to cause bladder cancer . These are renally excreted and exert a carcinogenic effect on the entire urinary system. After smoking, occupational exposure to carcinogens -namely, aromatic amines, polycyclic aromatic hydrocarbons, and chlorinated hydrocarbons- is viewed as the second most important risk factor. It has been suggested that roughly 20% of all bladder cancers are related to such exposure, mainly in industrial areas producing and processing paint, dye, metal, and petroleum products. As for other cancers, nutritional aspects have been attributed to bladder cancer risk . Exposure to arsenic in drinking water has been recognised as a cause of bladder cancer. In general, the differences in incidence and mortality by gender, race or socio-economic status reported in other studies can be explained by differences in habits or by other exposures.
Increasing evidence suggests that genetic predisposition has a significant influence on incidence, especially through its impact on susceptibility to other risk factors. The frequency of bladder cancer will nevertheless remain relatively unaffected due to the ongoing high prevalence of smoking, its main risk factor .
The pattern of bladder cancer in men displays some analogies with that of lung cancer, though it also reveals notable differences. The similarities are the higher risk in many towns situated in the provinces of Cadiz, Huelva and Seville, in Almería, and along the coast of the Valencian Region. The most marked contrasts with the pattern plotted by lung cancer are to be found in Extremadura, Asturias and the province of Barcelona. Towns in Cadiz, Seville and Huelva display excess risk in both sexes. The coincidence with excess risk of lung cancer among men across large parts of the country, points to the effect of smoking. In view of the singular spatial distribution of these towns, it would seem that determinants other than the high prevalence of smokers are present in the pattern of bladder cancer mortality in this area, since this same pattern is also observed in women in the first five-year period. There have been reports of excess risk in districts of Catalonia and its possible relationship with mining activity and the textile industry. A fuller discussion of these results, which includes suggestions of different hypotheses that seek to explain these patterns, may be consulted in a previous article . The maps show a change in the distribution of mortality in women, characterised by the appearance of excess mortality in the last five-year period in towns in Catalonia, Aragon and Navarre, as well as in Valencia and Alicante, which is probably linked to the increase in the prevalence of female smokers in these areas.
Among men in Spain, geographical patterns of mortality due to the most frequent cancers of the digestive system (stomach and colorectal), lung cancer and bladder cancer seem to be stable over time. Prostate cancer and the tumours studied in women show no defined spatial pattern, with the single exception of stomach cancer. Breast, colorectal and bladder cancer in women show signs of the possible appearance of a spatial pattern in the last five-year period, and should therefore be monitored.
The study was partially supported by a research grant from the Spanish Health Research Fund (FIS PI11/00871). Mortality data were supplied by the Spanish National Statistics Institute in accordance with a specific confidentiality protocol. Thanks to Olivier Nuñez for his comments about interpretation of some aspects of models results.
- Elliott P, Wartenberg D: Spatial epidemiology: current approaches and future challenges. Environ Health Perspect. 2004, 112: 998-1006.PubMed CentralView ArticlePubMedGoogle Scholar
- Lawson A, Biggeri A, Bohning D, Lesaffre E, Biggeri A, Viel JF, Best N: Disease Mapping and Risk Assessment for Public Health. 1999, Chichester: WileyGoogle Scholar
- López-Abente G, Ramis R, Pollán M, Aragonés N, Pérez-Gómez B, Gómez-Barroso D, Carrasco J, Lope V, García-Pérez J, Boldo E, García-Mendizabal M: Atlas Municipal de Mortalidad Por Cáncer En España, 1989-1998. 2006, Madrid: Instituto de Salud Carlos IIIGoogle Scholar
- Boyle P, Smans M: Atlas of Cancer Mortality in the European Union and the European Economic Area 1993-1997. IARC Scientific Publications nº 159. 2008, Lyon: International Agency for Research on CancerGoogle Scholar
- Pickle LW, Mungiole M, Jones GK, White AA: Atlas of United States Mortality. 1996, Hyattsville, Maryland: National Center for Health StatisticsGoogle Scholar
- Besag J, York J, Mollié A: Bayesian image restoration with two applications in spatial statistcs. Ann Inst Stat Math. 1991, 43: 1-59.View ArticleGoogle Scholar
- Knorr-Held L: Bayesian modelling of inseparable space-time variation in disease risk. Stat Med. 2000, 19: 2555-2567.View ArticlePubMedGoogle Scholar
- Martínez-Beneito MA, López-Quilez A, Botella-Rocamora P: An autoregressive approach to spatio-temporal disease mapping. Stat Med. 2008, 27: 2874-2889.View ArticlePubMedGoogle Scholar
- Bernardinelli L, Clayton D, Pascutto C, Montomoli C, Ghislandi M, Songini M: Bayesian analysis of space-time variation in disease risk. Stat Med. 1995, 14: 2433-2443.View ArticlePubMedGoogle Scholar
- Blangiardo M, Cameletti M, Baio G, Rue H: Spatial and spatio-temporal models with R-INLA. Spat Spatio-Temporal Epidemiol. 2013, 4: 33-49.View ArticleGoogle Scholar
- Abellan JJ, Richardson S, Best N: Use of space-time models to investigate the stability of patterns of disease. Environ Health Perspect. 2008, 116: 1111-1119.PubMed CentralView ArticlePubMedGoogle Scholar
- Aragonés N, Pérez-Gómez B, Pollán M, Ramis R, Vidal E, Lope V, García-Pérez J, Boldo E, López-Abente G: The striking geographical pattern of gastric cancer mortality in Spain: environmental hypotheses revisited. BMC Cancer. 2009, 9: 316-316.PubMed CentralView ArticlePubMedGoogle Scholar
- Pollán M, Ramis R, Aragonés N, Pérez-Gómez B, Gómez D, Lope V, García-Pérez J, Carrasco JM, García-Mendizábal MJ, López-Abente G: Municipal distribution of breast cancer mortality among women in Spain. BMC Cancer. 2007, 7: 78-PubMed CentralView ArticlePubMedGoogle Scholar
- López-Abente G, Aragonés N, Ramis R, Hernández-Barrera V, Pérez-Gómez B, Escolar-Pujolar A, Pollán M: Municipal distribution of bladder cancer mortality in Spain: possible role of mining and industry. BMC Public Health. 2006, 6: 17-PubMed CentralView ArticlePubMedGoogle Scholar
- The R-INLA project. http://www.r-inla.org/,
- R Development Core Team: R: A Language and Environment for Statistical Computing. 2005, Vienna, Austria: R Foundation for Statistical ComputingGoogle Scholar
- Waterhouse J, Muir CS, Correa P, Powell J: Cancer Incidence in Five Continents Vol. III. Volume III. IARC Scientific Publications nº 15. 1976, Lyon: International Agency for Research on CancerGoogle Scholar
- Pérez-Gómez B, Aragonés N, Pollán M, Suárez B, Lope V, Llácer A, López-Abente G: Accuracy of cancer death certificates in Spain: a summary of available information. Gac Sanit. 2006, 20 (Suppl 3): 42-51.View ArticlePubMedGoogle Scholar
- Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JWW, Comber H, Forman D, Bray F: Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013, 49: 1374-1403.View ArticlePubMedGoogle Scholar
- Sant M, Allemani C, Santaquilani M, Knijn A, Marchesi F, Capocaccia R: EUROCARE-4. Survival of cancer patients diagnosed in 1995-1999. Results and commentary. Eur J Cancer. 2009, 45: 931-991.View ArticlePubMedGoogle Scholar
- Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D: GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10. 2010, Lyon: International Agency for Research on CancerGoogle Scholar
- Correa P, Piazuelo MB: Helicobacter pylori Infection and gastric adenocarcinoma. US Gastroenterol Hepatol Rev. 2011, 7: 59-64.PubMed CentralPubMedGoogle Scholar
- López-Abente G, Ardanaz E, Torrella-Ramos A, Mateos A, Delgado-Sanz C, Chirlaque MD: Changes in colorectal cancer incidence and mortality trends in Spain. Ann Oncol. 2010, 21 (Suppl 3): iii76-iii82.PubMedGoogle Scholar
- Liang PS, Chen T-Y, Giovannucci E: Cigarette smoking and colorectal cancer incidence and mortality: systematic review and meta-analysis. Int J Cancer. 2009, 124: 2406-2415.View ArticlePubMedGoogle Scholar
- Hannan LM, Jacobs EJ, Thun MJ: The association between cigarette smoking and risk of colorectal cancer in a large prospective cohort from the United States. Cancer Epidemiol Biomark Prev. 2009, 18: 3362-3367.View ArticleGoogle Scholar
- Ferrari P, Jenab M, Norat T, Moskal A, Slimani N, Olsen A, TjÃ¸nneland A, Overvad K, Jensen MK, Boutron-Ruault M-C, Clavel-Chapelon F, Morois S, Rohrmann S, Linseisen J, Boeing H, Bergmann M, Kontopoulou D, Trichopoulou A, Kassapa C, Masala G, Krogh V, Vineis P, Panico S, Tumino R, van Gils CH, Peeters P, Bueno-de-Mesquita HB, OckÃ© MC, Skeie G, Lund E, et al: Lifetime and baseline alcohol intake and risk of colon and rectal cancers in the European prospective investigation into cancer and nutrition (EPIC). Int J Cancer. 2007, 121: 2065-2072.View ArticlePubMedGoogle Scholar
- Van Duijnhoven FJB, Bueno-De-Mesquita HB, Ferrari P, Jenab M, Boshuizen HC, Ros MM, Casagrande C, Tjønneland A, Olsen A, Overvad K, Thorlacius-Ussing O, Clavel-Chapelon F, Boutron-Ruault M-C, Morois S, Kaaks R, Linseisen J, Boeing H, Nöthlings U, Trichopoulou A, Trichopoulos D, Misirli G, Palli D, Sieri S, Panico S, Tumino R, Vineis P, Peeters PH, van Gils CH, Ocké MC, Lund E, et al: Fruit, vegetables, and colorectal cancer risk: the European prospective Investigation into cancer and nutrition. Am J Clin Nutr. 2009, 89: 1441-1452.View ArticlePubMedGoogle Scholar
- Murphy N, Norat T, Ferrari P, Jenab M, Bueno-de-Mesquita B, Skeie G, Dahm CC, Overvad K, Olsen A, Tjønneland A, Clavel-Chapelon F, Boutron-Ruault MC, Racine A, Kaaks R, Teucher B, Boeing H, Bergmann MM, Trichopoulou A, Trichopoulos D, Lagiou P, Palli D, Pala V, Panico S, Tumino R, Vineis P, Siersema P, van Duijnhoven F, Peeters PH, Hjartaker A, Engeset D, et al: Dietary fibre intake and risks of cancers of the colon and rectum in the European prospective investigation into cancer and nutrition (EPIC). PLoS One. 2012, 7: e39361-PubMed CentralView ArticlePubMedGoogle Scholar
- Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T, Clavel-Chapelon F, Kesse E, Nieters A, Boeing H, Tjonneland A, Overvad K, Martinez C, Dorronsoro M, Gonzalez CA, Key TJ, Trichopoulou A, Naska A, Vineis P, Tumino R, Krogh V, Bueno-de-Mesquita HB, Peeters PHM, Berglund G, Hallmans G, Lund E, Skeie G, Kaaks R, Riboli E, European Prospective Investigation into Cancer and Nutrition: Dietary fibre in food and protection against colorectal cancer in the European prospective investigation into cancer and nutrition (EPIC): an observational study. Lancet. 2003, 361: 1496-1501.View ArticlePubMedGoogle Scholar
- López-Abente G, García-Pérez J, Fernández-Navarro P, Boldo E, Ramis R: Colorectal cancer mortality and industrial pollution in Spain. BMC Public Health. 2012, 12: 589-PubMed CentralView ArticlePubMedGoogle Scholar
- Fernández-Navarro P, García-Pérez J, Ramis R, Boldo E, López-Abente G: Proximity to mining industry and cancer mortality. Sci Total Environ. 2012, 435–436: 66-73.View ArticlePubMedGoogle Scholar
- Segnan N, Patnick J, von Karsa L: European Guidelines for Quality Assurance in Colorectal Cancer Screening and Diagnosis - First Edition. 2010, Luxembourg: European Commission, Publications Office of the European UnionGoogle Scholar
- Ascunce N, Salas D, Zubizarreta R, Almazán Ibáñez J, Ederra M, Network of Spanish Cancer Screening Programmes (Red de Programas Espanoles de Cribado de Cancer): Cancer screening in Spain. Ann Oncol. 2010, 21 (Suppl 3): iii43-iii51.PubMedGoogle Scholar
- Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD: Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2013, 143 (5 Suppl): e1S-e29S.PubMed CentralView ArticlePubMedGoogle Scholar
- Quindos LS, Fernandez PL, Sainz C, Fuente I, Nicolas J, Quindos L, Arteche J: Indoor radon in a Spanish region with different gamma exposure levels. J Env Radioact. 2008, 99: 1544-1547.View ArticleGoogle Scholar
- Straif K, Cohen A, Samet JM: Air Pollution and Cancer. IARC Scientific Publications nº 161. 2013, Lyon: International Agency for Research on CancerGoogle Scholar
- Sánchez MJ, Payer T, De Angelis R, Larrañaga N, Capocaccia R, Martínez C, CIBERESP Working Group: Cancer incidence and mortality in Spain: estimates and projections for the period 1981-2012. Ann Oncol. 2010, 21 (Suppl 3): iii30-iii36.PubMedGoogle Scholar
- Chirlaque MD, Salmerón D, Ardanaz E, Galceran J, Martínez R, Marcos-Gragera R, Sánchez MJ, Mateos A, Torrella A, Capocaccia R, Navarro C: Cancer survival in Spain: estimate for nine major cancers. Ann Oncol. 2010, 21 (Suppl 3): iii21-iii29.PubMedGoogle Scholar
- Pollán M, Pastor-Barriuso R, Ardanaz E, Argüelles M, Martos C, Galcerán J, Sánchez-Pérez MJ, Chirlaque MD, Larrañaga N, Martínez-Cobo R, Tobalina MC, Vidal E, Marcos-Gragera R, Mateos A, Garau I, Rojas-Martín MD, Jiménez R, Torrella-Ramos A, Perucha J, Pérez-de-Rada ME, González S, Rabanaque MJ, Borràs J, Navarro C, Hernández E, Izquierdo A, López-Abente G, Martínez C: Recent changes in breast cancer incidence in Spain, 1980-2004. J Natl Cancer Inst. 2009, 101: 1584-1591.PubMed CentralView ArticlePubMedGoogle Scholar
- Dumitrescu RG, Cotarla I: Understanding breast cancer risk – where do we stand in 2005?. J Cell Mol Med. 2005, 9: 208-221.View ArticlePubMedGoogle Scholar
- World Cancer Research Fund/American Institute for Cancer Research: Food, Nutrition, Physical Activity, and the Prevention of Cancer: A Global Perspective. 2007, Washington DC: AICRGoogle Scholar
- Pike MC, Pearce CL, Wu AH: Prevention of cancers of the breast, endometrium and ovary. Oncogene. 2004, 23: 6379-6391.View ArticlePubMedGoogle Scholar
- IARC Working Group on the Evaluation of, Carcinogenic Risks to Humans: A Review of Human Carcinogens: Pharmaceuticals. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Vol 100A. 2008, Lyon: International Agency for Research on CancerGoogle Scholar
- Pollán M, Ascunce N, Ederra M, Murillo A, Erdozáin N, Alés-Martínez JE, Pastor-Barriuso R: Mammographic density and risk of breast cancer according to tumor characteristics and mode of detection: a Spanish population-based case-control study. Breast Cancer Res. 2013, 15 (1): R9-PubMed CentralView ArticlePubMedGoogle Scholar
- Robert SA, Strombom I, Trentham-Dietz A, Hampton JM, McElroy JA, Newcomb PA, Remington PL: Socioeconomic risk factors for breast cancer: distinguishing individual- and community-level effects. Epidemiol. 2004, 15: 442-450.View ArticleGoogle Scholar
- Larrañaga N, Galceran J, Ardanaz E, Franch P, Navarro C, Sánchez MJ, Pastor-Barriuso R, Prostate Cancer Working Group: Prostate cancer incidence trends in Spain before and during the prostate-specific antigen era: impact on mortality. Ann Oncol. 2010, 21 (Suppl 3): iii83-iii89.PubMedGoogle Scholar
- Liu H, Wang B, Han C: Meta-analysis of genome-wide and replication association studies on prostate cancer. Prostate. 2011, 71: 209-224.View ArticlePubMedGoogle Scholar
- Bosland MC: A perspective on the role of estrogen in hormone-induced prostate carcinogenesis. Cancer Lett. 2013, 334: 28-33.PubMed CentralView ArticlePubMedGoogle Scholar
- Kasper JS, Liu Y, Giovannucci E: Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study. Int J Cancer. 2009, 124: 1398-1403.PubMed CentralView ArticlePubMedGoogle Scholar
- Boudreau DM, Yu O, Johnson J: Statin use and cancer risk: a comprehensive review. Expert Opin Drug Saf. 2010, 9: 603-621.PubMed CentralView ArticlePubMedGoogle Scholar
- Allen NE, Key TJ, Appleby PN, Travis RC, Roddam AW, Tjønneland A, Johnsen NF, Overvad K, Linseisen J, Rohrmann S, Boeing H, Pischon T, Bueno-de-Mesquita HB, Kiemeney L, Tagliabue G, Palli D, Vineis P, Tumino R, Trichopoulou A, Kassapa C, Trichopoulos D, Ardanaz E, Larrañaga N, Tormo MJ, González CA, Quirós JR, Sánchez MJ, Bingham S, Khaw KT, Manjer J, et al: Animal foods, protein, calcium and prostate cancer risk: the European prospective investigation into cancer and nutrition. Br J Cancer. 2008, 98: 1574-1581.PubMed CentralView ArticlePubMedGoogle Scholar
- Burger M, Catto JWF, Dalbagni G, Grossman HB, Herr H, Karakiewicz P, Kassouf W, Kiemeney LA, La Vecchia C, Shariat S, Lotan Y: Epidemiology and risk factors of urothelial bladder cancer. Eur Urol. 2013, 63: 234-241.View ArticlePubMedGoogle Scholar
- Sievert KD, Amend B, Nagele U, Schilling D, Bedke J, Horstmann M, Hennenlotter J, Kruck S, Stenzl A: Economic aspects of bladder cancer: what are the benefits and costs?. World J Urol. 2009, 27: 295-300.PubMed CentralView ArticlePubMedGoogle Scholar
- Freedman ND, Silverman DT, Hollenbeck AR, Schatzkin A, Abnet CC: Association between smoking and risk of bladder cancer among men and women. JAMA. 2011, 306: 737-745.PubMed CentralView ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/535/prepub
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