Skip to main content

Table 3 Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with disease-free survival (DFS)

From: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

Variable

Univariate analysis

Multivariate analysis

 

HR

CI(95%)

Pvalue

HR

CI(95%)

Pvalue

Sex

      

   Female

1

     

   Male

0.966

0.662-1.409

0.856

   

Age at surgery, years

      

   < 65

1

     

   ≥ 65

1.228

0.841-1.794

0.287

   

Tumor location

      

   Colon

1

  

1

  

   Rectum

1.602

1.083-2.368

0.018

1.874

1.255-2.801

0.001

TNM stage

      

   I-II

1

  

1

  

   III-IV

2.851

1.933-4.204

< 0.001

2.383

1.572-3.614

< 0.001

pT (invasion depth)

      

   T1-T2

1

     

   T3-T4

1.398

0.822-2.379

0.216

   

pN (lymph node metastasis)

      

   N0

1

     

   N1-N2

2.351

1.607-3.439

< 0.001

   

pM (distant metastasis)

      

   M0

1

     

   M1

7.250

4.619-11.38

< 0.001

   

Differentiation grade

      

   Well and Moderate

1

  

1

  

   Poorly

3.082

1.830-5.188

< 0.001

2.988

1.746-5.114

< 0.001

Preoperative CEA level

      

   < 5 ng/ml

1

  

1

  

   ≥ 5 ng/ml

1.748

1.196-2.556

0.004

1.192

0.789-1.801

0.405

Preoperative CA19-9 level

      

   < 60 U/ml

1

  

1

  

   ≥ 60 U/ml

1.926

1.146-3.236

0.013

1.779

1.035-3.056

0.037

Phospho-MEK5 protein

      

   Normal expression

1

  

1

  

   Overexpression

1.898

1.264-2.850

0.002

1.388

0.900-2.141

0.139

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us