Author and year | Patients (n) | TirAEs (%) | Flare, n(%) | G1-2, n(%) | G3-4, n(%) | New onset irAEs n(%) | G1-2, n(%) | G3-4, n(%) | Discont-inuation, n(%) | ORR (%) | DCR (%) |
---|---|---|---|---|---|---|---|---|---|---|---|
Bhatlapenumarthi-2020 [17] | 24 | NA | 5(20.8%) | NA | NA | NA | NA | NA | NA | NA | NA |
Brown-2021 [18] | 11 | NA | 7(63.6%) | 5(45.5%) | 2(18.2%) | 5(45.5%) | NA | NA | NA | 45.5% | 54.5% |
Cortellini-2019 [19] | 10 | 5(50%) | 1(10.0%) | 1(10.0%) | 0 | 4(40.0%) | 4(40.0%) | 0 | NA | NA | NA |
Danlos-2018 [20] | 7 | NA | 1(14.3%) | NA | NA | NA | NA | NA | NA | NA | NA |
Efuni-2021 [21] | 22 | 16(72.7%) | 12(54.5%) | NA | NA | 7(31.8%) | 5(22.7%) | 2(9.1%) | 9(40.9%) | NA | NA |
Gutzmer-2017 [22] | 9 | 7(77.8%) | 5(55.6%) | 3(33.3%) | 2(22.2%) | 2(22.2%) | 2(22.2%) | 0 | 0 | 44.4% | 44.4% |
Hoa-2021 [23] | 19 | 12(63.2%) | 8(42.1%) | 8(42.1%) | 0 | 7(36.8%) | 4(21.0%) | 3(15.8%) | NA | NA | 42.1% |
Johnson-2016 [24] | 10 | 7(70.0%) | 5(50.0%) | NA | NA | 3(30.0%) | 0 | 3(30.0%) | NA | 30.0% | NA |
Kähler-2017 [25] | 14 | 7(50.0%) | 6(42.9%) | NA | NA | 4(28.6%) | 2(14.3%) | 2(14.3%) | 1(7.1%) | 0 | 0 |
Kaur-2019 [26] | 5 | NA | 1(20.0%) | NA | NA | NA | NA | NA | 0 | NA | NA |
Lee-2016 [27] | 8 | 8(100.0%) | 6(75.0%) | 4(50.0%) | 2(25.0%) | NA | NA | 4(50.0%) | 5(62.5%) | 50.0% | 87.5% |
Leonardi-2018 [28] | 25 | 12(48.0%) | 10(40.0%) | 7(28.0%) | 2(8.0%) | 6(24.0%) | 4(16.0%) | 2(8.0%) | 6(24.0%) | NA | NA |
Loriot-2020 [29] | 7 | NA | 1(14.3%) | 0 | 1(14.3%) | NA | NA | NA | NA | NA | NA |
Lusa-2022 [30] | 45 | 27(60.0%) | 13(28.9%) | 13(28.9%) | 0 | 20(44.4%) | NA | 8(17.8%) | 16(35.6%) | 13.3% | 17.8% |
Machado-2023 [31] | 58 | NA | 15(25.9%) | NA | NA | 14(24.1%) | NA | NA | NA | NA | NA |
Martinez Chanza-2020 [32] | 35 | 23(65.7%) | 18(51.4%) | NA | NA | 13(37.1%) | NA | NA | NA | NA | NA |
Menzies-2016 [33] | 27 | NA | 14(51.9%) | NA | NA | NA | NA | NA | NA | NA | NA |
Mitchell-2018 [34] | 12 | 10(83.3%) | 10(83.3%) | 8(66.7%) | 2(16.7%) | 3(25.0%) | 1(8.3%) | 2(16.7%) | 3(25.0%) | 50.0% | 66.7% |
Mooradian-2019 [35] | 6 | NA | 6(100%) | NA | NA | 2(33.3%) | NA | NA | 2(33.3%) | 33.3% | 66.7% |
Panhaleux-2020 [36] | 17 | NA | 4(23.5%) | 0 | 4(23.5%) | 10(58.8%) | 9(52.9%) | 1(5.9%) | NA | 41.2% | 58.8% |
Richter-2017 [37] | 16 | 6(37.5%) | 1(6.25%) | 1(6.2%) | 0 | 5(31.3%) | 1(6.25%) | 4(25.0%) | 6(37.5%) | NA | NA |
Tison-2019 [38] | 39 | 23(58.9%) | 19(48.7%) | 13(40.6%) | 3(9.4%) | NA | NA | NA | 6(15.3%) | NA | NA |
Van der Kooij-2021 [39] | 227 | NA | NA | NA | NA | NA | NA | 29(12.8%) | NA | NA | NA |