Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients

BMC Cancer

Table 2 IHC evaluation of the most common markers related with hypoxia in repeatedly resected gliomas

IHC analysis of hypoxia related markers
sample	resection	MGMT prom. methylation	EGFR amplified yes/no	ATRX - L = loss; P = positivity	p53	Olig2%	SOX10%	SOX11%	MEOX2%	CD44%	MERTK %	Vimentin %	ZEB1%	ZEB2%	TWIST %	HIF1a %	HIF1b %	STAT3%	pSTAT3%
Le	1st	no	no	L	mut	65	0	0	35	100	10	35	95	10	70	1	0	0	20
	2nd	no	no	P	mut	=	-	-	-	=	-	↑	-	↑	↓	-	↑	-	↑
	3rd	no	no	P	mut	↓	=	↑	↓	=	↓	↓	↓	↓	=	↑	↓	↑	↑
	4th	no	no	P	mut	↑	=	↑	↑	=	↑	↑	↑	↑	↑	↓	↑	↑	↑
Pu	1st	no	no	P	mut	95	0	10	95	95	-	100	-	100	100	0	60	100	40
	2nd	no	no	L	mut	↓	↑	↓	↓	↑	-	↓	75	=	↓	=	↓	-	↑
	3rd	no	no	P	mut	↑	↓	↑	↑	↑	27	↑	↑	=	↑	=	↑	=	↑
Ku	1st	no	no	P	wt	100	85	80	0	95	10	12	95	100	40	0	80	60	35
	2nd	no	no	P	wt	↓	↑	↓	=	↑	-	↓	↓	-	-	=	=	-	↑
Do	1st	yes	yes	L	wt	85	0	3	5	87	5	100	100	100	100	0	0	-	5
	2nd	yes	yes	P	wt	↓	=	↓	↑	↑	-	↓	=	-	=	=	↑	70	↑
Jo	1st	yes	yes	L	wt	40	0	0	15	100	5	95	35	100	0	0	15	-	85
	2nd	yes	yes	P	wt	↓	=	↑	↓	=	↑	↑	↑	=	↑	↑	-	50	↑
Du	1st	no	yes	P	wt	32	0	15	25	100	-	100	-	100	5	0	35	60	35
	2nd	no	yes	L	wt	↓	↑	↓	↓	=	5	↓	60	↓	=	=	↓	60	↑
Bi	1st	yes	no	P	mut	50	40	20	10	100	20	82	65	100	50	0	20	90	85
	2nd	yes	no	P	mut	↓	↓	↓	↓	=	↓	↓	↓	=	↓	↑	=	↓	↓
Ná	1st	no	no	L	wt	60	50	5	0	100	20	80	95	100	90	0	40	95	70
	2nd	no	no	L	wt	↓	↓	↓	=	=	↓	↓	↓	↓	↓	=	↓	↓	↑

ISSN: 1471-2407