Fig. 5
From: ESCO2’s oncogenic role in human tumors: a pan-cancer analysis and experimental validation
Analysis of ESCO2-related regulatory pathways. (A) The intersecting genes of DEGs between the ESCO2-high and ESCO2-low groups. (B) Gene Ontology analysis of the 2419 DEGs. FDR < 0.05 was considered significantly enriched. (C) The intersecting genes of DEGs with a high correlation to ESCO2 using spearman’s correlation analysis (p < 0.05, Cor > 0.4). (D) Bar plot of the top 30 genes with the largest number of adjacent nodes in the PPI network of ESCO2-related regulatory genes. (E) Western blot results manifested the down-regulated expression of CDK1 compared with the si‐con group in A498 cells.The optical density ratio of bands represent objective proteins to band of β-actin was calculated. (F) The ESCO2-related regulatory gene functions were mainly enriched in mitotic cell cycle and DNA metabolic processes. The interactive network was constructed using the meta scape online platform