TM-positive group (N = 76) | TM-negative group (N = 59) | |||||||
---|---|---|---|---|---|---|---|---|
Total (N = 135) | Cancer (N = 41) | No cancer (N = 35) | p* | Cancer (N = 9) | No cancer (N = 50) | p** | p*** | |
Inflammatory markers, n#/N (%) med [IQR] | ||||||||
CRP, mg/L (N<5.0) | 135/135 (100) 78.8 [35.3-141.4] | 78.6 [44.7–124.0] | 52.7 [25.7-149.5] | 0.87 | 134.0 [67.9–172.0] | 81.4 [35.1-139.1] | 0.17 | 0.67 |
ESR§, mm | 40/135 (29.6) 61 [34.8–85.5] | 11/41 (26.8) 58.0 [30.5–79.5] | 8/35 (22.9) 70.0 [37.5–84.0] | 0.89 0.39 | 3/9 (33.3) 79.5 [24 0.5-129.3] | 18/50 (36.0) 63.0 [49.5–81.8] | 1 0.11 | 0.25 0.39 |
Fibrinogen, g/L (N:1.8–3.5) | 77/135 (57) 5.4 [4.2–6.8] | 24/41 (58.5) 5.3 [4.6–6.7] | 16/35 (45.7) 4.9 [3.6–6.2] | 0.37 0.04 | 5/9 (55.3) 6.9 [3.9–8.2] | 32/50 (64.0) 5.7 [4.2–2.1] | 0.92 0.15 | 0.31 0.17 |
Haptoglobin, g/L (N:0.4–2.8) | 25/41 (61.0) 2.6 [1.4–4.1] | 8/13 (61.5) 3.2 [1.7–3.6] | 2/8 (25.0) 1.4 [0.2–1.9] | NA < 1.10− 4 | 2/2 (100) 5.4 [5.1–5.6] | 13/18 (72.2) 2.6 [2.1–4.2] | NA 0.39 | 0.12 0.15 |
Ferritin, µg/l (N:10–241) | 73/115 (63.4) 363.5 [157.5-706.5] | 18/33 (54.6) 379 [137–558] | 22/32 (68.8) 383 [240–692] | 0.35 0.54 | 6/8 (75.0) 736.5 [289.5-953.5] | 27/42 (64.3) 331.0 [153.7-672.3] | 0.85 0.03 | 0.77 0.32 |
Albumin, g/L (N:32–46) | 89/134 (66.4) 28.1 [25-34.1] | 30/40 (75.0) 27.9 [24.9–31.9] | 22/35 (62.9) 28.2 [25.4–34.6] | 0.38 0.39 | 7/9 (77.8) 25.6 [23.5–30.2] | 30/50 (60.0) 29. [24.0-35.4] | 0.47 0.13 | 0.54 0.73 |
Inflammatory profile on SPE | 69/117 (59.0) | 15/27 (38.5) | 17/33 (48.6) | 0.96 | 6/9 (66 0.7) | 31/48 (62.0) | 1 | 0.27 |
Other laboratory variables, n/N (%) med [IQR] | ||||||||
WBCs, 103/mm3(N:4.0–10.0) | 47/135 (34.8) 8.1 [6.2–11.3] | 16/41 (39.0) 8.5 [6.8–12.0] | 13/35 (37.1) 7.9 [5.7–13.8] | 1 0.59 | 4/9 (44.4) 10.3 [7.8–15.7] | 14/50 (28.0) 7.9 [6.2–10.3] | 0.58 0.01 | 0.45 0.26 |
Hemoglobin, g/dL (N:11.5–16) | 69/135 (51.1) 11.4 [9.9–12.4] | 22/41 (53.7) 11 [9.4–12.1] | 21/35 (60.0) 11.4 [9.9–12.4] | 0.75 1 | 4/9 (44.4) 11.5 [10.0-12.6] | 22/50 (44.0) 11.5 [10.4–12.3] | 1 0.89 | 0.27 0.43 |
Platelets, 103/mm3 (N:150–400) | 40/135 (29.6) 290 [226.5–431) | 10/41 (24.4) 278.5 [230.8-396.5] | 10/35 (28.6) 520 [469.3-615.5] | 0.88 0.83 | 1/9 (11.1) 254.0 [241.3-294.5] | 19/50 (38.0) 304.5 [237.0-463.5] | NA 0.22 | 0.45 0.46 |
LDH, U/L (N:120–246) | 102/107 (95.3) 660 [354–602] | 31/32 (96.9) 520.5 [382.7-746.5] | 23/25 (92.00) 435.0 [354–582] | 0.83 NA | 7/7 (100) 341 [308–593] | 41/43 (95.4) 414 [351–560] | 1 NA | 1 1 |
Blood TMs, n# /N (%) med [IQR] | ||||||||
CEA, µg/L (N < 2.5-5) | 28/128 (21.9) 1.5 [0.9-3.0] | 17/40 (42.5) 2.7 [1.0–6.0] | 11/35 (31.4) 1.7 [1.2–3.9] | 0.06 NA | 0/8 1.5 [1.0-2.2] | 0/45 1.1 [0.8–1.9] | NA NA | NA NA |
Total PSA, ng/mL (N < 4) | 10/66 (13.3) 1.4 [0.6–2.8] | 4/17(23.5 )1.4 [0.7–3.6] | 6/19 (31.6) 2.4 [1.2–4.6] | 0.60 NA | 0/5 0.7 [0.4–1.6] | 0/25 1.2 [0.5–1.9] | NA NA | NA NA |
AFP, ng/mL (N < 8) | 7/118 (5.9) 3.0 [1.9–4.5] | 5/35 (14.3) 3.5 [2.4–4.6] | 2/31 (6.5) 3.3 [2.1–4.2] | NA NA | 0/7 3.3 [1.7–4.4] | 0/45 2.2 [1.7–3.5] | NA NA | NA NA |
CA 125, U/mL (N < 35) | 38/96 (39.6) 18.0 [9.6–61.9] | 22/31 (71.0) 124.5 [28.6-210.9] | 16/27 (59.3) 38.4 [11.9–57.3] | 0.51 NA | 0/6 15.0 [9.2–17.8] | 0/32 9.5 [6.7–13.1] | NA NA | NA NA |
CA 15 − 3, U/mL (N < 32.4) | 17/91 (18.7) 17.4 [11-26.4] | 11/30 (36.7) 25.7 (17.3–65.9] | 6/25 (24.0) 17.7 [11.2–31.5] | 0.46 NA | 0/5 11.2 [10.9–15.2] | 0/31 12.60 [7.5–17.8] | NA NA | NA NA |
CA 19 − 9, U/mL (N < 37) | 19/121(15.7) 11.6 [7.8–21.7] | 15/34 (44.1) 19.5 [8.9-218.9] | 4/34 (11.8) 13.9 [8.4–28.4] | 0.004 NA | 0/9 9.7 [5.3–10.1] | 0/44 10.1 [6.4–14.1] | NA NA | NA NA |
Calcitonin, pg/mL (N < 10) | 6/55 (10.9) 4.4 [2.8–10.8] | 1/17 (5.9) 4.3 [3.2–5.9] | 5/17 (29.4) 15.0 [9.0-19.5] | NA NA | 0/3 3.8 [3.5–4.2] | 0/18 1.6 [0.9–3.6] | NA NA | NA NA |
NSE, µg/L (N < 18.3) | 19/63 (30.2) 12 [9.8–22] | 12/22 (54.6) 22.4 [10.3–45.7] | 7/20 (35.0) 12.2 [9.7–20.4] | 0.33 NA | 0/4 10.3 [9.8–12.1] | 0/17 10.8 [8.5–13.8] | NA NA | NA NA |