Fig. 4
From: CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis
MiR-122-5p and PKM2 were the downstream target of circPHGDH. (A) Prediction of binding sites of miR-122-5p in circPHGDH. The MUT version of circPHGDH is presented. (B) Relative luciferase activity determined 48 h after transfection of HEK293T cells with miR-122-5p mimic/NC or circPHGDH WT/Mut. Data are presented as means ± SD. **P < 0.01. (C) Prediction of binding sites of miR-122-5p within the 3’UTR of PKM2. The MUT version of 3’-UTR-PKM2 is shown. (D) Relative luciferase activity determined 48 h after transfection of HEK293T cells with miR-122-5p mimic/NC or 3’UTR-PKM2 WT/Mut. Data are presented as means ± SD. **P < 0.01