Table 1 MR analysis of the causal relationship between immune cells and renal cancer

Activated & secreting CD4 regulatory T cell %CD4 + T cell

MR Egger

4

0.78 (0.29–2.07)

6.69 × 10^–1

Weighted median

4

0.73 (0.48–1.13)

1.62 × 10^–1

Inverse variance weighted

4

0.68 (0.48–0.96)

2.92 × 10^–2

Simple mode

4

0.76 (0.43–1.35)

4.18 × 10^–1

Weighted mode

4

0.76 (0.45–1.31)

3.99 × 10^–1

CD4-CD8- T cell %T cell

MR Egger

3

0.92 (0.07–11.73)

9.59 × 10^–1

Weighted median

3

1.81 (1.16–2.85)

9.65 × 10^–3

Inverse variance weighted

3

1.61 (1.02–2.55)

4.07 × 10^–2

Simple mode

3

1.95 (1.02–3.72)

1.82 × 10^–1

Weighted mode

3

1.91 (1.16–3.13)

1.25 × 10^–1

HLA DR on CD14 + CD16 + monocyte

MR Egger

5

0.93 (0.42–2.07)

8.65 × 10^–1

Weighted median

5

0.86 (0.72–1.02)

8.31 × 10^–2

Inverse variance weighted

5

0.84 (0.71–0.99)

3.92 × 10^–2

Simple mode

5

0.68 (0.47–0.96)

9.71 × 10^–2

Weighted mode

5

0.87 (0.71–1.06)

2.43 × 10^–1

BAFF-R on IgD- CD38 + B cell

MR Egger

3

0.71 (0.38–1.34)

4.86 × 10^–1

Weighted median

3

0.73 (0.55–0.97)

2.78 × 10^–2

Inverse variance weighted

3

0.69 (0.53–0.89)

5.74 × 10^–3

Simple mode

3

0.72 (0.49–1.07)

2.44 × 10^–1

Weighted mode

3

0.73 (0.53–1.00)

1.86 × 10^–1

CD19 on IgD + CD24- B cell

MR Egger

3

1.01 (0.17 − 5.80)

9.96 × 10^–1

Weighted median

3

0.62 (0.37 − 1.04)

7.16 × 10^–2

Inverse variance weighted

3

0.59 (0.37 − 0.95)

2.87 × 10^–2

Simple mode

3

0.63 (0.30 − 1.32)

3.46 × 10^–1

Weighted mode

3

0.63 (0.35 − 1.12)

2.55 × 10^–1