Fig. 3
The metabolic enrichment and pathways analyses of PC vs. PDXG1 and PDXG1 vs. PDXG3. Figure 3A&B. The metabolic enrichment analysis based on metabolomic difference of PC vs. PDXG1 and PDXG1 vs. PDXG3, respectively. Y axis represents the top 15 metabolic difference-related metabolic sets. Figure 3C&D. The topological analysis of the metabolic pathway involved in metabolomic difference of PC vs. PDXG1 and PDXG1 vs. PDXG3, respectively. X axis represent the impact of metabolic pathway, and Y axis represent the–log(p-value) of pathway. Each dot represents a pathway, and the color of dot represent p-value of pathway ranging from low (red) to high (yellow). For PC vs. PDXG1, label dots represented the statistically significant metabolic pathways based on p-value less than 1 × 10− 4 and pathway impact higher than 0.1. For PDXG1 vs. PDXG3, label dots represented the statistically significant metabolic pathways based on p-value less than 1 × 10− 3 and pathway impact higher than 0.1. Figure 3E&F. The metabolic network analyses based on metabolomic difference of PC vs. PDXG1 and PDXG1 vs. PDXG3, respectively. Each dot represents a pathway, and the color of dot represent p-value of pathway ranging from low (red) to high (yellow). Dashed lines represent significant connection between metabolic pathways