Table 2 Univariate and multivariate Cox regression analysis for overall survival in the rIII-IVA* NPC

Age (years)

 < 45

1 (reference)

 ≥ 45

1.090 (0.685–1.733)

0.717

Sex

 Male

1 (reference)

 Female

1.372 (0.775–2.428)

0.278

rEBV DNA (copies/ml)

 Undetectable

1 (reference)

 Detectable

1.612 (0.899–2.889)

0.109

 Unkown

rLactate dehydrogenase (U/L)

 < 240

1 (reference)

 ≥ 240

1.104 (0.347–3.518)

0.867

 Unkown

/

rC-reactive protein (mg/L)

 < 10.5

1 (reference)

1 (reference)

 ≥ 10.5

2.784 (1.615–4.798)

< 0.001

2.348 (1.336–4.127)

0.003

rAlbumin (g/L)

 < 39.4

1 (reference)

1 (reference)

 ≥ 39.4

0.195 (0.107–0.356)

< 0.001

0.224 (0.120–0.418)

< 0.001

rNLR

 < 3.7

1 (reference)

 ≥ 3.7

1.372 (0.855–2.203)

0.190

 Unkown

/

Treatment

 Palliative treatment

1 (reference)

1 (reference)

 Re-radiotherapy + Salvage Surgery

0.340 (0.210–0.551)

< 0.001

0.407 (0.249–0.666)

< 0.001

PET/CT

 No

1 (reference)

1 (reference)

 Yes

0.519 (0.294–0.917)

0.024

0.476 (0.267–0.847)

0.012